Modulating inflammation through the negative regulation of NF‐κB signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3mir0817-346rrr
Abstract: Immune system activation is essential to thwart the invasion of pathogens and respond appropriately to tissue damage. However, uncontrolled inflammation can result in extensive collateral damage underlying a diverse range of auto‐inflammatory, hyper‐inflammatory, and neoplastic… read more here.
Keywords: modulating inflammation; inflammation; regulation signaling; immune system ... See more keywords
Negative regulation of innate lymphoid cell responses in inflammation and cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Immunology letters"
DOI: 10.1016/j.imlet.2019.01.011
Abstract: The immune system employs an array of effector cells to ensure tissue homeostasis and protection against pathogens. Lymphocytes belonging to both the adaptive and innate branches share several functions, comprising the ability to directly kill… read more here.
Keywords: innate lymphoid; negative regulation; inflammation cancer;
Positive and negative regulation of carbon nanotube catalysts through encapsulation within macrocycles
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05183-8
Abstract: One of the most attractive applications of carbon nanomaterials is as catalysts, due to their extreme surface-to-volume ratio. The substitution of C with heteroatoms (typically B and N as p- and n-dopants) has been explored… read more here.
Keywords: positive negative; carbon; encapsulation within; negative regulation ... See more keywords
Negative Regulation of RIG-I by Tim-3 Promotes H1N1 Infection
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Investigations"
DOI: 10.1080/08820139.2022.2113407
Abstract: ABSTRACT The mechanisms by which retinoic acid-inducible gene I (RIG-I), a critical RNA virus sensor, is regulated in many biological and pathological processes remain to be determined. Here, we demonstrate that T cell immunoglobulin and… read more here.
Keywords: tim; h1n1 infection; type interferon; negative regulation ... See more keywords
Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.1101/2024.04.02.587770
Abstract: Mitotic anaphase onset is a key cellular process tightly regulated by multiple kinases. The involvement of mitogen-activated protein kinases (MAPKs) in this process has been established in Xenopus egg extracts. However, the detailed regulatory cascade… read more here.
Keywords: negative regulation; mapk; regulation apc; activation ... See more keywords
Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0172603
Abstract: ICAT (Inhibitor of β-CAtenin and TCF) is a small acidic protein that negatively regulates β-catenin co-transcriptional activity by competing with TCF/LEF factors in their binding to β-catenin superhelical core. In melanoma cells, ICAT competes with… read more here.
Keywords: catenin; icat residues; transcriptional activity; icat ... See more keywords
Negative Regulation of Cathepsins by β-Amyloid
Sign Up to like & getrecommendations! Published in 2024 at "eNeuro"
DOI: 10.1523/eneuro.0258-23.2023
Abstract: Genome wide association study (GWAS) uncovered Alzheimer's disease (AD) risk genes linked to the endo-lysosomal pathway. This pathway seems to be the gateway of protein aggregates, such as tau and α-synuclein, to the cytoplasm. Furthermore,… read more here.
Keywords: negative regulation; regulation cathepsins; cathepsins amyloid; endo lysosomal ... See more keywords
Negative Regulation and Protective Function of Natural Killer Cells in HIV Infection: Two Sides of a Coin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.842831
Abstract: Natural killer (NK) cells play an important immunologic role, targeting tumors and virus-infected cells; however, NK cells do not impede the progression of human immunodeficiency virus (HIV) infection. In HIV infection, NK cells exhibit impaired… read more here.
Keywords: infection; natural killer; hiv infection; negative regulation ... See more keywords
Negative Regulation of ULK1 by microRNA-106a in Autophagy Induced by a Triple Drug Combination in Colorectal Cancer Cells In Vitro
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12020245
Abstract: Colorectal cancer (CRC) is among the top three most deadly cancers worldwide. The survival rate for this disease has not been reduced despite the treatments, the reason why the search for therapeutic alternatives continues to… read more here.
Keywords: combination; colorectal cancer; autophagy; cancer ... See more keywords