Pan‐senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.457
Abstract: ABSTRACT Cellular senescence, an irreversible proliferative arrest, functions in tissue remodeling during development and is implicated in multiple aging‐associated diseases. While senescent cells often manifest an array of senescence‐associated phenotypes, such as cell cycle arrest,… read more here.
Keywords: negative regulator; analysis; senescence; regulator cellular ... See more keywords
The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.02.027
Abstract: Summary The circadian clock and the hypoxia-signaling pathway are regulated by an integrated interplay of positive and negative feedback limbs that incorporate energy homeostasis and carcinogenesis. We show that the negative circadian regulator CRY1 is… read more here.
Keywords: negative regulator; hif; clock protein; circadian clock ... See more keywords
SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.251
Abstract: This corrects the article DOI: 10.1038/onc.2014.445 read more here.
Keywords: negative regulator; mesenchymal transition; transition hepatocellular; regulator epithelial ... See more keywords
The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0468-y
Abstract: Nowrouzi A, et al. High-resolution analysis of the human T-cell receptor repertoire. Nat Commun. 2015;6:8081. 10. de Leval L, Bisig B, Thielen C, Boniver J, Gaulard P. Molecular classification of T-cell lymphomas. Crit Rev Oncol… read more here.
Keywords: negative regulator; ubash3b sts; sts negative; phosphatase ubash3b ... See more keywords
USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00301-4
Abstract: Despite much progress in the comprehension of the complex process of somatic cell reprogramming, many questions regarding the molecular mechanism of regulation remain to be answered. At present, the knowledge on the negative regulation of… read more here.
Keywords: negative regulator; cbx4 cbx6; usp26 functions; functions negative ... See more keywords
Negative regulator of GDF15 signalling identified
Sign Up to like & getrecommendations! Published in 2022 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-022-00661-y
Abstract: 0123456789();: Nature reviews | Endocrinology Original article Chow, C. F. W. et al. Body weight regulation via MT1-MMP-mediated cleavage of GFRAL. Nat. Metab. https://doi.org/ 10.1038/s42255-022-00529-5 related articles Wang, D. et al. GDF15: emerging biology and… read more here.
Keywords: regulator gdf15; signalling identified; gdf15 signalling; negative regulator ... See more keywords
The Wnt receptor Ryk is a negative regulator of mammalian dendrite morphogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06140-z
Abstract: The unique dendritic architecture of a given neuronal subtype determines its synaptic connectivity and ability to integrate into functional neuronal networks. It is now clear that abnormal dendritic structure is associated with neuropsychiatric and neurodegenerative… read more here.
Keywords: negative regulator; dendrite morphogenesis; wnt receptor; receptor ryk ... See more keywords
The abscisic acid signaling negative regulator OsPP2C68 confers drought and salinity tolerance to rice
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-91226-2
Abstract: Clade A type 2 C protein phosphatases (PP2CAs) are core regulatory factors in the plant abscisic acid (ABA) signaling pathway. They play crucial roles in response to abiotic stress. However, a comprehensive understanding of the… read more here.
Keywords: negative regulator; salinity; rice; stress ... See more keywords
PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2514948122
Abstract: Immunotherapy modalities have revolutionized cancer treatment for a number of metastatic and treatment-refractory tumor types. Still, many malignancies that lack T cell infiltration and are termed immunologically "cold" fail to respond to these modalities. One… read more here.
Keywords: cancer; ppt1 negative; negative regulator; regulator sting ... See more keywords
Plant Tomosyn Is a Negative Regulator of SNARE-Mediated Secretion in Pollen
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DOI: 10.1104/pp.19.01145
Abstract: Vesicle transport is one of those molecular processes that is easy to take for granted. From cell expansion and polarized growth to protein regulation and signaling, vesicle trafficking plays its unsung part. We tend to… read more here.
Keywords: negative regulator; snare mediated; plant; tomosyn negative ... See more keywords
HIP1R Is a Negative Regulator of PD-L1.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2018-200
Abstract: HIP1R targets PD-L1 for lysosomal degradation, thereby enhancing the antitumor activity of T cells. read more here.
Keywords: hip1r negative; negative regulator;