Two negative regulators of biofilm development exhibit functional divergence in conferring virulence potential to Candida albicans
Sign Up to like & getrecommendations! Published in 2019 at "FEMS Yeast Research"
DOI: 10.1093/femsyr/foy078
Abstract: Abstract Candida albicans, a human pathogen, carries an expanded family of Zn(II)2Cys6 transcription factors. A CTG clade‐specific protein Zcf32 and its closely related protein Upc2, a well‐conserved transcription factor across the various fungal species, belong… read more here.
Keywords: transcription; biofilm development; negative regulators; virulence ... See more keywords
SOCS: negative regulators of cytokine signaling for immune tolerance.
Sign Up to like & getrecommendations! Published in 2021 at "International immunology"
DOI: 10.1093/intimm/dxab055
Abstract: Cytokines are important intercellular communication tools for immunity. Many cytokines promote gene transcription and proliferation through the JAK/STAT (Janus kinase / signal transducers and activators of transcription) and the Ras/ERK (GDP/GTP-binding rat sarcoma protein /… read more here.
Keywords: negative regulators; cytokine signaling; immune tolerance; socs negative ... See more keywords
Negative regulators of platelet activation and adhesion
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13910
Abstract: Platelets are small anucleated cells that constantly patrol the cardiovascular system to preserve its integrity and prevent excessive blood loss where the vessel lining is breached. Their key challenge is to form a hemostatic plug… read more here.
Keywords: negative regulators; regulators platelet; platelet activation; activation adhesion ... See more keywords
Abstract 227: In vivo functional genomics screen to uncover tumor intrinsic negative regulators of NK cell-mediated tumor cell killing
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-227
Abstract: Natural killer cells are innate immune cells whose activity is gated by activating and inhibitory receptors that bind ligands on potential target cells. NK cell gene signatures are associated with improved survival in several indications,… read more here.
Keywords: cell; cell killing; negative regulators; tumor cell ... See more keywords
Evolution of negative immune regulators
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DOI: 10.1371/journal.ppat.1007913
Abstract: Hosts must recognize pathogen invasion and respond rapidly. The need for speed requires a low threshold for triggering a response, causing occasional false alarms. Host immune systems therefore require strong negative regulators to shut down… read more here.
Keywords: negative regulators; immune regulators; negative immune; evolution negative ... See more keywords
Resveratrol Enhances Temozolomide Efficacy in Glioblastoma Cells through Downregulated MGMT and Negative Regulators-Related STAT3 Inactivation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119453
Abstract: Chemoresistance blunts the efficacy of temozolomide (TMZ) in the treatment of glioblastoma (GBM). Elevated levels of O6-methylguanine-DNA methyltransferase (MGMT) and activation of signal transducer and of transcription 3 (STAT3) have been reported to correlate with… read more here.
Keywords: glioblastoma; stat3 inactivation; negative regulators; gbm ... See more keywords