N-protein-RNA interaction is a drug target in a negative strand RNA virus
Sign Up to like & getrecommendations! Published in 2021 at "Virus Research"
DOI: 10.1016/j.virusres.2021.198298
Abstract: The negative strand RNA virus family contains many human pathogens. Finding new antiviral drug targets against this class of human pathogens is one of the significant healthcare needs. Nucleocapsid proteins of negative strand RNA viruses… read more here.
Keywords: strand rna; rna; drug; strand ... See more keywords
Structural basis for 3C and 3CD recruitment by enteroviral genomes during negative-strand RNA synthesis
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DOI: 10.1038/s41467-025-64376-0
Abstract: Enteroviral replication-linked cloverleaf RNAs recruit the viral 3CD protein, a fusion of 3C protease and 3D RNA-dependent RNA-polymerase, for negative-strand synthesis during genome replication. However, the structures and mechanisms of this virological process remain unclear.… read more here.
Keywords: negative strand; replication; rna; structural basis ... See more keywords
Strand-specific affinity of host factor hnRNP C1/C2 guides positive to negative-strand ratio in Coxsackievirus B3 infection
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DOI: 10.1080/15476286.2019.1629208
Abstract: ABSTRACT Coxsackievirus B3 is an enterovirus, with positive-sense single-stranded RNA genome containing ‘Internal Ribosome Entry Site’ (IRES) in the 5ʹUTR. Once sufficient viral proteins are synthesized in the cell from the input RNA, viral template… read more here.
Keywords: positive negative; hnrnp; strand; negative strand ... See more keywords