Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2‐induced pseudo‐allergic reaction
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7445
Abstract: Mas‐related G protein‐coupled receptor X2 (MRGPRX2) mediates mast cells (MCs) activation, which is a key target for the treatment of allergic diseases. However, there are few drugs targeting MRGPRX2. Leukocyte mono‐immunoglobulin‐like receptor 3 (CD300f) is… read more here.
Keywords: negatively regulated; pseudo allergic; regulated mrgprx2; mrgprx2 ... See more keywords
HMGB1 was negatively regulated by HSF1 and mediated the TLR4/MyD88/NF-κB signal pathway in asthma.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.117120
Abstract: AIMS The present study explored the function and regulatory mechanism of High mobility group box 1 (HMGB1) in asthma. MAIN METHODS OVA (ovalbumin)-induced asthmatic mice model and LPS-treated cellular model were established in this study.… read more here.
Keywords: hmgb1; negatively regulated; signal pathway; regulated hsf1 ... See more keywords
Sestrin2 Negatively Regulates Casein Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion or Supplementation in Cow Mammary Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b00716
Abstract: Sestrin2 (SESN2) negatively regulates the mammalian target of rapamycin complex 1 (mTORC1) pathway and casein synthesis in response to amino acid (AA) depletion in cow mammary epithelial cells (CMECs); however, the underlying mechanism is unclear.… read more here.
Keywords: sh3bp4; mtorc1 pathway; negatively regulates; negatively regulated ... See more keywords
SEMA6D, Negatively Regulated by miR-7, Contributes to C28/I2 chondrocyte's Catabolic and Anabolic Activities via p38 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9674221
Abstract: MiR-7 has been recognized as an osteoarthritis (OA-)-promoting factor, but the specific downstream pathway of miR-7 still remains unknown. Further investigation of the molecular regulatory mechanism of miR-7 might help develop a novel therapeutic method… read more here.
Keywords: sema6d; sema6d negatively; negatively regulated; regulated mir ... See more keywords
Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine"
DOI: 10.1186/s10020-018-0021-x
Abstract: BackgroundHigh mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. HMGB1 interacts with toll-like receptors (TLRs) but contradictory evidence regarding its identity as a TLR2… read more here.
Keywords: hmgb1; tlr2; negatively regulated; tail domain ... See more keywords