The glycoprotein mucin‐1 negatively regulates GalNAc transferase 5 expression in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13532
Abstract: Aberrant expression of the glycoprotein mucin‐1 (MUC1) has been associated with pancreatic cancer progression and metastasis as a result of mediating the oncogenic transcriptional regulation of target genes. In the present study, we demonstrate that… read more here.
Keywords: glycoprotein mucin; mucin negatively; negatively regulates; pancreatic cancer ... See more keywords
The cyclin‐dependent kinase inhibitor p27Kip1 interacts with the aryl hydrocarbon receptor and negatively regulates its transcriptional activity
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14434
Abstract: p27Kip1 functions to coordinate cell cycle progression through the inhibition of cyclin‐dependent kinase (CDK) complexes. p27Kip1 also exerts distinct activities beyond CDK‐inhibition, including functioning as a transcriptional regulator. The aryl hydrocarbon receptor (AhR) is a… read more here.
Keywords: hydrocarbon receptor; p27kip1; dependent kinase; cyclin dependent ... See more keywords
Tao Negatively Regulates BMP Signaling During Neuromuscular Junction Development in Drosophila
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22681
Abstract: The coordinated growth and development of synapses is critical for all aspects of neural circuit function and mutations that disrupt these processes can result in various neurological defects. Several anterograde and retrograde signaling pathways, including… read more here.
Keywords: tao; bmp signaling; tao negatively; negatively regulates ... See more keywords
O-GlcNAcylation of myocyte-specific enhancer factor 2D negatively regulates insulin secretion from pancreatic β-cells.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.036
Abstract: Patients with type 2 diabetes often exhibit impairments in both glucose-induced insulin secretion (GIIS) and incretin-induced insulin secretion (IIIS). These phenotypes are associated with altered glucose metabolism in pancreatic β-cells, although the molecular mechanisms remain… read more here.
Keywords: negatively regulates; glcnacylation; secretion; pancreatic cells ... See more keywords
Black carp RIPK1 negatively regulates MAVS-mediated antiviral signaling during the innate immune activation.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2020.103726
Abstract: Receptor-interacting serine/threonine protein kinase 1 (RIPK1) is an important regulator of necroptosis and involved in innate immune response in human and mammal; however, its function in teleost fish mains largely unknown. In this paper, the… read more here.
Keywords: carp; innate immune; carp ripk1; negatively regulates ... See more keywords
MPK3- and MPK6-Mediated ICE1 Phosphorylation Negatively Regulates ICE1 Stability and Freezing Tolerance in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.09.025
Abstract: Low temperatures affect plant growth, development, productivity, and ecological distribution. Expression of the C-repeat-binding factor (CBF) transcription factors is induced by cold stress, which in turn activates downstream cold-responsive (COR) genes that are required for… read more here.
Keywords: freezing tolerance; ice1 stability; negatively regulates; mpk3 mpk6 ... See more keywords
PEDV nsp16 negatively regulates innate immunity to promote viral proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Virus Research"
DOI: 10.1016/j.virusres.2019.03.005
Abstract: Abstract Type-I IFNs (IFN-I) provide a key mediator of innate antiviral response during virus proliferation. Porcine epidemic diarrhea virus (PEDV), which causes diarrhea in swine of all ages, is a worldwide-distributed alphacoronavirus with economic importance.… read more here.
Keywords: pedv nsp16; pedv; negatively regulates; proliferation ... See more keywords
Sestrin2 Negatively Regulates Casein Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion or Supplementation in Cow Mammary Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b00716
Abstract: Sestrin2 (SESN2) negatively regulates the mammalian target of rapamycin complex 1 (mTORC1) pathway and casein synthesis in response to amino acid (AA) depletion in cow mammary epithelial cells (CMECs); however, the underlying mechanism is unclear.… read more here.
Keywords: sh3bp4; mtorc1 pathway; negatively regulates; negatively regulated ... See more keywords
USP13 negatively regulates antiviral responses by deubiquitinating STING
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15534
Abstract: STING (also known as MITA) is critical for host defence against viruses and the activity of STING is regulated by ubiquitination. However, the deubiquitination of STING is not fully understood. Here, we show that ubiquitin-specific… read more here.
Keywords: negatively regulates; responses deubiquitinating; usp13 negatively; antiviral responses ... See more keywords
Angiomotin-like 2 interacts with and negatively regulates AKT
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.101
Abstract: Angiomotin-like 2 (AMOTL2) is a member of Angiomotin family proteins, which are potent inhibitors for the Hippo pathway effector YAP. However, additional cellular functions of AMOTL2 besides YAP inhibition are largely unknown. Here, we reported… read more here.
Keywords: yap akt; angiomotin like; negatively regulates; regulates akt ... See more keywords
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00834-7
Abstract: Interleukin-3 (IL-3) is a hematopoietic growth factor and critical regulator of inflammatory response such as sepsis. IL-3 binds to IL-3 receptor α (IL-3Rα), which is then associated with IL-3Rβ to initiate signaling. How IL-3-triggered physiological… read more here.
Keywords: regulates triggered; negatively regulates; k48 linked; march3 ... See more keywords