Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes and Neighboring Endogenous Genes
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DOI: 10.3389/fnmol.2018.00385
Abstract: Transgenic mouse lines are routinely employed to label and manipulate distinct cell types. The transgene generally comprises cell-type specific regulatory elements linked to a cDNA encoding a reporter or other protein. However, off-target expression seemingly… read more here.
Keywords: insertion; endogenous genes; site; expression ... See more keywords