No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
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DOI: 10.1038/s41598-017-04472-4
Abstract: Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first… read more here.
Keywords: dna; mutation frequencies; cancer; neil1 neil2 ... See more keywords
NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487
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DOI: 10.3390/ijms22094542
Abstract: DNA damage caused by reactive oxygen species may result in genetic mutations or cell death. Base excision repair (BER) is the major pathway that repairs DNA oxidative damage in order to maintain genomic integrity. In… read more here.
Keywords: ogg1 upon; dna; inhibition; backup ... See more keywords