In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases.
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DOI: 10.1039/c7md00510e
Abstract: Potent, selective, and cell active small molecule kinase inhibitors are useful tools to help unravel the complexities of kinase signaling. As the biological functions of individual kinases become better understood, they can become targets of… read more here.
Keywords: nek family; kinase; starting points; chemical starting ... See more keywords
Prognostic value and immune infiltration of the NEK family in clear cell renal cell carcinoma
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DOI: 10.1097/md.0000000000038961
Abstract: Clear cell renal cell carcinoma (ccRCC) is a fatal urological malignancy. Members of the never-in mitosis gene A (NIMA)-related kinase (NEK) family have been found to participate in the progression of several cancers and could… read more here.
Keywords: immune infiltration; family; nek family; clear cell ... See more keywords
Integrative Analysis of the Expression Levels and Prognostic Values for NEK Family Members in Breast Cancer
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DOI: 10.3389/fgene.2022.798170
Abstract: Background: In the latest rankings, breast cancer ranks first in incidence and fifth in mortality among female malignancies worldwide. Early diagnosis and treatment can improve the prognosis and prolong the survival of breast cancer (BC)… read more here.
Keywords: nek family; prognosis; family; family members ... See more keywords
NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types
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DOI: 10.3390/cancers15072067
Abstract: Simple Summary Kinases are biomolecules that control cellular reactions essential for life. Disruptions in kinase expression and activity lead to the development of diseases such as cancer. A great deal of funding and scientific effort… read more here.
Keywords: nek family; family; survival outcomes; expression ... See more keywords