Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation
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DOI: 10.1371/journal.pbio.2004663
Abstract: Nuclear factor κB (NF-κB) is a transcription factor important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, and senescence. Dysregulation of NF-κB and its upstream regulator IκB kinase (IKK) contributes to the pathogenesis of… read more here.
Keywords: binding domain; ikk; nemo binding; activation ... See more keywords
Targeting NF-κB by the Cell-Permeable NEMO-Binding Domain Peptide Improves Albuminuria and Renal Lesions in an Experimental Model of Type 2 Diabetic Nephropathy
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DOI: 10.3390/ijms21124225
Abstract: Diabetic nephropathy (DN) is a multifactorial disease characterized by hyperglycemia and close interaction of hemodynamic, metabolic and inflammatory factors. Nuclear factor-κB (NF-κB) is a principal matchmaker linking hyperglycemia and inflammation. The present work investigates the… read more here.
Keywords: peptide; binding domain; cell permeable; nemo binding ... See more keywords