Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer
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DOI: 10.1080/2162402x.2019.1673125
Abstract: ABSTRACT The murine MC-38 colorectal cancer model is a commonly used model for cancer with high mutational burden, which is sensitive for immune checkpoint immunotherapy. We set out to analyze endogenous CD8+ T cell responses… read more here.
Keywords: cd8 cell; cell responses; cell; neo epitope ... See more keywords
Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides
Sign Up to like & getrecommendations! Published in 2019 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-019-0595-z
Abstract: BackgroundTargeting epitopes derived from neo-antigens (or “neo-epitopes”) represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 + T cell response, and there is… read more here.
Keywords: binding peptides; mutation type; mhc binding; neo epitope ... See more keywords
An mRNA-based workflow validating neo-epitope presentation through HLA-I/peptide affinity purification
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DOI: 10.3389/fimmu.2025.1566461
Abstract: Presentation of human leukocyte antigen (HLA)-class I-restricted neo-epitopes is key for inducing an adaptive cytotoxic T-lymphocyte response against cancer. Validating presentation of these cancer-specific neo-epitopes following delivery to antigen-presenting cells (APCs) is critical to advance… read more here.
Keywords: purification; mrna based; hla; neo epitope ... See more keywords