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Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2019.1673125
Abstract: ABSTRACT The murine MC-38 colorectal cancer model is a commonly used model for cancer with high mutational burden, which is sensitive for immune checkpoint immunotherapy. We set out to analyze endogenous CD8+ T cell responses…
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Keywords:
cd8 cell;
cell responses;
cell;
neo epitope ... See more keywords
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Published in 2019 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-019-0595-z
Abstract: BackgroundTargeting epitopes derived from neo-antigens (or “neo-epitopes”) represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 + T cell response, and there is…
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Keywords:
binding peptides;
mutation type;
mhc binding;
neo epitope ... See more keywords