Cost-Effectiveness of Neoadjuvant-Adjuvant Treatment Strategies for Women With ERBB2 (HER2)–Positive Breast Cancer
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DOI: 10.1001/jamanetworkopen.2020.27074
Abstract: This economic evaluation modeled the cost-effectiveness of 5 neoadjuvant-adjuvant treatment strategies for women with ERBB2-positive breast cancer. read more here.
Keywords: effectiveness neoadjuvant; neoadjuvant adjuvant; adjuvant treatment; treatment strategies ... See more keywords
Neoadjuvant-Adjuvant vs Neoadjuvant-Only PD-1 and PD-L1 Inhibitors for Patients With Resectable NSCLC
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DOI: 10.1001/jamanetworkopen.2024.1285
Abstract: Key Points Question Is administration of programmed cell death 1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors both before and after surgery (neoadjuvant-adjuvant treatment) associated with better outcomes than administration of the therapy solely… read more here.
Keywords: treatment; neoadjuvant adjuvant; patients resectable; neoadjuvant inhibitors ... See more keywords
Postrecurrence Treatment in Neoadjuvant or Adjuvant FDA Registration Trials
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DOI: 10.1001/jamaoncol.2024.1569
Abstract: This systematic review examines the proportion and quality of postrecurrence treatment among patients in US Food and Drug Administration (FDA) registration trials of anticancer therapy in the neoadjuvant or adjuvant setting. read more here.
Keywords: fda registration; postrecurrence treatment; neoadjuvant adjuvant; registration trials ... See more keywords
Real-world neoadjuvant and adjuvant Trastuzumab-containing regimen patterns and their association with survival among patients with operable HER2-positive breast cancer from 2007 to 2021
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DOI: 10.1007/s10549-024-07552-y
Abstract: Chemotherapy in combination with trastuzumab is the standard neoadjuvant and adjuvant therapy for human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Assessing the regimens administered to patients with HER2-positive BC in the real… read more here.
Keywords: breast cancer; cancer; regimen patterns; neoadjuvant adjuvant ... See more keywords
Duodenal adenocarcinoma: neoadjuvant and adjuvant therapy strategies
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DOI: 10.1080/21678707.2019.1684257
Abstract: ABSTRACT Introduction: Duodenal adenocarcinoma (DA) is a relatively rare gastrointestinal malignancy associated with poor outcomes. The mainstay of treatment is surgical resection with regional lymphadenectomy but recurrence rates remain high. Due to the relatively low… read more here.
Keywords: neoadjuvant adjuvant; adenocarcinoma neoadjuvant; therapy; adjuvant therapy ... See more keywords
Feasibility of neoadjuvant and adjuvant intraperitoneal chemotherapy in patients with advanced epithelial ovarian cancer
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DOI: 10.1097/md.0000000000022100
Abstract: Abstract Intraperitoneal (IP) chemotherapy is believed to prolong the survival of patients with advanced ovarian cancer after primary debulking surgery. However, there is little knowledge about IP chemotherapy in the setting of neoadjuvant chemotherapy, and… read more here.
Keywords: chemotherapy; patients advanced; feasibility neoadjuvant; ovarian cancer ... See more keywords
Evaluation of dexrazoxane effect on preventing acute cardiac arrhythmia in patients with breast cancer treated with neoadjuvant/adjuvant anthracycline‐based chemotherapy
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DOI: 10.1111/ijcp.14705
Abstract: Adding dexrazoxane to the treatment during neoadjuvant/adjuvant anthracycline‐based chemotherapy in patients with breast cancer prevents the development of heart failure. In this study, we investigated whether dexrazoxane has a protective effect on arrhythmia resulting from… read more here.
Keywords: patients breast; neoadjuvant adjuvant; adjuvant anthracycline; based chemotherapy ... See more keywords
812 Urelumab (anti-CD137 agonist) in combination with vaccine and nivolumab treatments is safe and associated with pathologic response as neoadjuvant and adjuvant therapy for resectable pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0812
Abstract: Background Data analysis of specimens from prior clinical trials identified the immune co-simulatory molecule CD137 within the tumor microenvironment(TME) of pancreatic ductal adenocarcinoma(PDAC) that remain to be activated following vaccine induced T cell and PD-1… read more here.
Keywords: cd137 agonist; trial; anti cd137; neoadjuvant adjuvant ... See more keywords
Abstract CT285: KEYNOTE-689: A phase 3 study of neoadjuvant and adjuvant pembrolizumab plus standard of care (SOC) in locally advanced (LA) head and neck squamous cell carcinoma (HNSCC)
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DOI: 10.1158/1538-7445.am2020-ct285
Abstract: Background: In phase 2 studies (NCT02296684 and NCT02641093), neoadjuvant and adjuvant pembrolizumab demonstrated a pathological response (PR) and acceptable safety in patients with high-risk, resectable, LA HNSCC. KEYNOTE-689 (NCT03765918) is a randomized, open-label, phase 3… read more here.
Keywords: keynote 689; phase; neoadjuvant adjuvant; hnscc ... See more keywords
Efficacy and safety of perioperative, neoadjuvant, or adjuvant immunotherapy alone or in combination with chemotherapy in early-stage non-small cell lung cancer: a systematic review and meta-analysis of randomized clinical trials
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DOI: 10.1177/17588359241284929
Abstract: Background: Neoadjuvant (NE), adjuvant (AD), and perioperative (PE) immunotherapies have gained validation in early-stage non-small cell lung cancer (NSCLC) trials. However, a comprehensive assessment of their comparative efficacy and safety is lacking. Objectives: To compare… read more here.
Keywords: neoadjuvant adjuvant; immunotherapy; early stage; stage ... See more keywords
A phase II study of atezolizumab as neoadjuvant and adjuvant therapy in patients (pts) with resectable non-small cell lung cancer (NSCLC).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.tps8580
Abstract: TPS8580Background: Trials of neoadjuvant and adjuvant chemotherapy have demonstrated an absolute survival benefit of 5% for patients with early stage disease. Atezolizumab is a humanized IgG1 monoclonal antibody that inhibits PD-L1 from binding to its… read more here.
Keywords: phase; neoadjuvant adjuvant; study; atezolizumab neoadjuvant ... See more keywords