A Dynamic Clinical Calculator for Estimating Conditional Recurrence-Free Survival After Total Neoadjuvant Therapy for Rectal Cancer and Either Surgery or Watch-and-Wait Management
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DOI: 10.1001/jamanetworkopen.2022.33859
Abstract: Key Points Question Can a previously validated clinical calculator be adapted to estimate the risk of rectal cancer recurrence dynamically at different time points for patients who defer surgery after complete response to neoadjuvant therapy?… read more here.
Keywords: free survival; neoadjuvant therapy; recurrence; rectal cancer ... See more keywords
Perioperative Therapy in Early-Stage Lung Cancer.
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DOI: 10.1001/jamaoncol.2022.1940
Abstract: Neoadjuvant Therapy Neoadjuvant therapy refers to any treatment that is given for cancer before surgery, with the goal of making the surgery more likely to be successful and improve the chance of long-term survival. The… read more here.
Keywords: lung cancer; neoadjuvant therapy; early stage; therapy ... See more keywords
Targeted axillary dissection after neoadjuvant therapy in breast cancer
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DOI: 10.1002/bjs.10626
Abstract: The presence of nodal metastases is an important prognostic factor used to direct locoregional and systemic therapies. The use of neoadjuvant therapy has been shown to eliminate nodal metastases in between 40 and 75 per… read more here.
Keywords: seed; per cent; dissection; neoadjuvant therapy ... See more keywords
A practical framework for the targeted use of total neoadjuvant therapy for rectal cancer
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DOI: 10.1002/cncr.34149
Abstract: Total neoadjuvant therapy (TNT) for rectal cancer is the preoperative delivery of radiation or chemoradiotherapy as well as systemic chemotherapy for the purpose of improving treatment completion rates and decreasing toxicity, maximizing the primary tumor… read more here.
Keywords: neoadjuvant therapy; cancer practical; total neoadjuvant; rectal cancer ... See more keywords
Impact of neoadjuvant therapy on postoperative outcomes after pancreaticoduodenectomy
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DOI: 10.1002/jso.25183
Abstract: Surgical resection provides the only potentially curative treatment of pancreatic cancer. Neoadjuvant chemotherapy and/or radiation (NAT) is used to downstage patients with borderline resectable tumors. The objective of this study was to examine the postoperative… read more here.
Keywords: impact neoadjuvant; outcomes pancreaticoduodenectomy; neoadjuvant therapy; postoperative outcomes ... See more keywords
Impact of neoadjuvant therapy followed by laparoscopic radical gastrectomy with D2 lymph node dissection in Western population: A multi-institutional propensity score-matched study.
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DOI: 10.1002/jso.26657
Abstract: BACKGROUND AND OBJECTIVES In the setting of a minimally invasive approach, we aimed to compare short and long-term postoperative outcomes of patients treated with neoadjuvant therapy (NAT) + surgery or upfront surgery in Western population. METHODS All… read more here.
Keywords: node dissection; gastrectomy lymph; western population; propensity score ... See more keywords
Reply to: “Impact of neoadjuvant therapy followed by laparoscopic radical gastrectomy with D2 lymph node dissection in Western population: a multi‐institutional propensity score matched study”
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26733
Abstract: Dear Editor, We appreciate with interest the paper written by Bracale et al. entitled “Impact of neoadjuvant therapy followed by laparoscopic radical gastrectomy with D2 lymph node dissection in Western population: a multi‐institutional propensity score… read more here.
Keywords: laparoscopic radical; neoadjuvant therapy; impact neoadjuvant; gastrectomy ... See more keywords
MRI‐detected extramural vascular invasion (mrEMVI) as the best predictive factor to identify candidates to total neoadjuvant therapy in locally advanced rectal cancer
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DOI: 10.1002/jso.26818
Abstract: Chemotherapy in locally advanced rectal cancer (LARC) is shifting from an adjuvant setting to a total neoadjuvant therapy (TNT) strategy, that relies on distant metastases (DM) risk prediction. This study aims to assess the accuracy… read more here.
Keywords: locally advanced; neoadjuvant therapy; total neoadjuvant; rectal cancer ... See more keywords
Total neoadjuvant therapy is associated with improved overall survival and pathologic response in pancreatic adenocarcinoma
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DOI: 10.1002/jso.26906
Abstract: Few studies have evaluated outcomes of total neoadjuvant therapy (TNT) compared with single modality neoadjuvant therapy (SMNT) or surgery first (SF) for pancreatic ductal adenocarcinoma (PDAC). read more here.
Keywords: therapy associated; neoadjuvant therapy; therapy; total neoadjuvant ... See more keywords
Neoadjuvant therapy use and association with postoperative outcomes and overall survival in patients with extrahepatic cholangiocarcinoma
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DOI: 10.1002/jso.27112
Abstract: Evidence for neoadjuvant therapy (NAT) in extrahepatic cholangiocarcinoma (eCCA) is limited. Our objectives were to: (1) characterize treatment trends, (2) identify factors associated with receipt of NAT, and (3) evaluate associations between NAT and postoperative… read more here.
Keywords: postoperative outcomes; neoadjuvant therapy; therapy use; extrahepatic cholangiocarcinoma ... See more keywords
Neoadjuvant therapy does not impact the biliary microbiome in patients with pancreatic cancer.
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DOI: 10.1002/jso.27281
Abstract: BACKGROUND Pancreatic adenocarcinoma (PDAC) often impinges on the biliary tree and obstruction necessitates stent placement increasing the risk of surgical site infections (SSIs). We sought to explore the impact of neoadjuvant therapy on the biliary… read more here.
Keywords: biliary microbiome; impact; impact biliary; neoadjuvant therapy ... See more keywords