A Potent Micron Neoantigen Tumor Vaccine GP‐Neoantigen Induces Robust Antitumor Activity in Multiple Tumor Models
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201496
Abstract: Therapeutic tumor neoantigen vaccines have been widely studied given their good safety profile and ability to avoid central thymic tolerance. However, targeting antigen‐presenting cells (APCs) and inducing robust neoantigen‐specific cellular immunity remain challenges. Here, a… read more here.
Keywords: system; antitumor; tumor; neoantigen ... See more keywords
Biosynthetic neoantigen displayed on bacteria derived vesicles elicit systemic antitumour immunity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12289
Abstract: Abstract Neoantigens derived from mutant proteins in tumour cells could elicit potent personalized anti‐tumour immunity. Nevertheless, the layout of vaccine vehicle and synthesis of neoantigen are pivotal for stimulating robust response. The power of synthetic… read more here.
Keywords: bacteria derived; neoantigen; bdvs neo; immunity ... See more keywords
Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth
Sign Up to like & getrecommendations! Published in 2020 at "Translational Oncology"
DOI: 10.1016/j.tranon.2020.100856
Abstract: The immunogenic clonal-fraction threshold in heterogeneous solid-tumor required to induce effective bystander-killing of non-immunogenic subclones is unknown. Pancreatic cancer poses crucial challenges for immune therapeutic interventions due to low mutational-burden and consequent lack of neoantigens.… read more here.
Keywords: neoantigen; pancreatic cancer; cancer; growth ... See more keywords
Nanovaccine Based on a Biepitope Antigen to Potentiate the Immunogenicity of a Neoantigen.
Sign Up to like & getrecommendations! Published in 2023 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.2c00742
Abstract: Specific neoantigens are promising candidates for personalized cancer vaccines and immunotherapies, whereas the low immunogenicity and physicochemical variability are the main challenges in clinical trials. Herein, based on the rational design of neoantigens, we developed… read more here.
Keywords: biepitope; neoantigen; immunogenicity; biepitope nanovaccines ... See more keywords
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer
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DOI: 10.1038/nature24462
Abstract: Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors, yet the relevant antigens… read more here.
Keywords: neoantigen; long term; survivors pancreatic; term survivors ... See more keywords
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2023.2168640
Abstract: ABSTRACT Introduction Cancer vaccine represents a promising strategy toward personalized immunotherapy, and its therapeutic potency highly relies on the specificity of tumor antigens. Among these extensively studied tumor antigens, neoantigens, a type of short synthetic… read more here.
Keywords: immunotherapy; neoantigen; tumor; biomaterials assisted ... See more keywords
The mutant neoantigen specific T cell is a personalized immunotherapy in refractory solid tumour
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz253.054
Abstract: Abstract Background Immune checkpoint inhibitors are an important therapy. However, their essence is nonspecific and efficiency of single usage is not satisfactory. The mutant neoantigen specific T (Nas-T) cell, as an adoptive cell treatment, is… read more here.
Keywords: neoantigen; neoantigen specific; cell personalized; personalized immunotherapy ... See more keywords
The role of tumour neoantigens in the differential response to immunotherapy (IO) in EGFR and BRAF mutated lung cancers: Quantity or quality?
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz253.084
Abstract: Abstract Background Lung cancer patients with activating EGFR mutations tend to respond poorly to IO, but this is not true for all activating mutation driven lung cancers. Recent data show that patients with BRAF mutations… read more here.
Keywords: neoantigen; egfr; braf; advisory consultancy ... See more keywords
Combination Immune Treatment of a Highly Aggressive Orthotopic Murine Glioblastoma With Checkpoint Blockade Inhibition and Neoantigen Vaccination
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgery"
DOI: 10.1093/neuros/nyz310_153
Abstract: The treatment of glioblastoma remains a challenge for modern therapy. Checkpoint blockade inhibitors (CBI), designed to block inhibitory T-cell signaling, represent attractive potential therapeutic interventions. However, glioblastoma response rates to CBI remain low. To this… read more here.
Keywords: glioblastoma; neoantigen; treatment; combination ... See more keywords
153 NEO-PTC-01 (BNT-221), an autologous neoantigen-specific T-cell product for adoptive cell therapy of metastatic melanoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0153
Abstract: Background Neoantigens are tumor-specific antigens that are important in the anti-tumor immune response. These antigens are not subject to central immune tolerance and are therefore potentially more immunogenic than tumor-associated antigens. NEO-STIM®, our propriety ex… read more here.
Keywords: neoantigen; melanoma; cell responses; specific cell ... See more keywords
Abstract 4949: Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigen
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-4949
Abstract: The impact of intratumor heterogeneity (ITH) and the neoantigen landscape on T cell immunity is poorly understood. ITH is a widely recognized feature of solid tumors and poses distinct challenges related to the development of… read more here.
Keywords: neoantigen; feature; melanoma; immunological ignorance ... See more keywords