Targeting B7-H3 enhances the efficacy of neoantigen-based cancer vaccine in combination with radiotherapy
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Vaccines"
DOI: 10.1038/s41541-025-01132-x
Abstract: The clinical response to immune checkpoint blockade (ICB) is limited in the majority of patients with colorectal cancer. These immune checkpoint proteins may not only inhibit T-cell-mediated antitumor immunity but also attenuate antigen presentation, including… read more here.
Keywords: cancer; based cancer; response; efficacy neoantigen ... See more keywords
Advancing nanotechnology for neoantigen-based cancer theranostics.
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DOI: 10.1039/d3cs00162h
Abstract: Neoantigens play a pivotal role in the field of tumour therapy, encompassing the stimulation of anti-tumour immune response and the enhancement of tumour targeting capability. Nonetheless, numerous factors directly influence the effectiveness of neoantigens in… read more here.
Keywords: cancer theranostics; advancing nanotechnology; nanotechnology; neoantigen based ... See more keywords
Neoantigen-based personalized DC vaccine for lung cancer: An update of translational study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e20674
Abstract: e20674 Background: DC vaccine is a promising strategy for cancer therapy. We conducts a personalized, neoantigen-loaded DC therapy trial in advanced NSCLC (NCT02956551 & ChiCTR-ONC-16009100). Here we provide the updated data. Methods: Advanced lung cancer… read more here.
Keywords: neoantigen based; based personalized; lung cancer; cancer ... See more keywords
A first-in-human study to evaluate a personalized neoantigen-based mRNA-loaded dendritic cell vaccine, in combination with ablation, in patients with hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.e14513
Abstract: e14513 Background: Local recurrence of Hepatocellular Carcinoma (HCC) following potentially curative resection or ablation is an inevitable risk. T cells recognizing neoantigens are present in most cancers including HCC and offer a specific and highly… read more here.
Keywords: based mrna; neoantigen; ablation; cell ... See more keywords
Breaking down physical barriers: strategies to improve lymphocyte infiltration for effective neoantigen-based therapies
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DOI: 10.3389/fimmu.2025.1614228
Abstract: The cancer genomic instability drives the generation of neoantigens, making them ideal targets for immunotherapy. Neoantigen-specific tumor-infiltrating lymphocytes achieve precise tumor cell killing by recognizing neoantigens on the tumor surface, but their efficacy is limited… read more here.
Keywords: physical barriers; neoantigen; based therapies; tumor ... See more keywords
Neoantigen-Based Immunotherapy in Lung Cancer: Advances, Challenges and Prospects
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DOI: 10.3390/cancers17121953
Abstract: Simple Summary Lung cancer, a leading malignancy with delayed diagnosis and poor prognosis. Neoantigen-based immunotherapy has emerged as a precision strategy, targeting tumor-specific antigens generated by somatic mutations. Unlike tumor-associated antigens, neoantigens are exclusive to… read more here.
Keywords: lung cancer; neoantigen based; tumor; lung ... See more keywords
Current Trends in Neoantigen-Based Cancer Vaccines
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DOI: 10.3390/ph16030392
Abstract: Cancer immunotherapies are treatments that use drugs or cells to activate patients’ own immune systems against cancer cells. Among them, cancer vaccines have recently been rapidly developed. Based on tumor-specific antigens referred to as neoantigens,… read more here.
Keywords: current trends; based cancer; cancer vaccines; neoantigen based ... See more keywords
Neoantigen Cancer Vaccines: Generation, Optimization, and Therapeutic Targeting Strategies
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DOI: 10.3390/vaccines10020196
Abstract: Alternatives to conventional cancer treatments are highly sought after for high-risk malignancies that have a poor response to established treatment modalities. With research advancing rapidly in the past decade, neoantigen-based immunotherapeutic approaches represent an effective… read more here.
Keywords: cancer; optimization; neoantigen based; neoantigen ... See more keywords