Neoantigen prediction and the need for validation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3932
Abstract: 815 disorders3,4. This has led to a high degree of business-level uncertainty regarding how such treatments should be priced and reimbursed5. Given these uncertainties, research organizations might not be easily able to hand off their… read more here.
Keywords: need validation; neoantigen prediction; research; prediction need ... See more keywords
Accounting for proximal variants improves neoantigen prediction
Sign Up to like & getrecommendations! Published in 2018 at "Nature genetics"
DOI: 10.1038/s41588-018-0283-9
Abstract: Recent efforts to design personalized cancer immunotherapies use predicted neoantigens, but most neoantigen prediction strategies do not consider proximal (nearby) variants that alter the peptide sequence and may influence neoantigen binding. We evaluated somatic variants… read more here.
Keywords: proximal variants; accounting proximal; somatic variants; neoantigen prediction ... See more keywords
ProGeo-Neo v2.0: A One-Stop Software for Neoantigen Prediction and Filtering Based on the Proteogenomics Strategy
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13050783
Abstract: A proteogenomics-based neoantigen prediction pipeline, namely ProGeo-neo, was previously developed by our team to predict neoantigens, allowing the identification of class-I major histocompatibility complex (MHC) binding peptides based on single-nucleotide variation (SNV) mutations. To improve… read more here.
Keywords: stop software; neoantigen prediction; one stop; prediction ... See more keywords