Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abl5447
Abstract: The accurate identification of antitumor T cell receptors (TCRs) represents a major challenge for the engineering of cell-based cancer immunotherapies. By mapping 55 neoantigen-specific TCR clonotypes (NeoTCRs) from 10 metastatic human tumors to their single-cell… read more here.
Keywords: cell; metastatic human; reactive cells; tumor ... See more keywords
Effect of neoantigen reactive T cells combined with chemotherapy and radiation on survival in advanced pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e15756
Abstract: e15756 Background: Pancreatic cancer (PC) is one of the most aggressive and death-relating malignancy. Gemcitabine (GEM) is the key agent in the first-line standard regimen for advanced PC, which is mostly diagnosed at advanced stage… read more here.
Keywords: cancer; day; reactive cells; survival ... See more keywords
Advanced HCC Patient Benefit From Neoantigen Reactive T Cells Based Immunotherapy: A Case Report
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.685126
Abstract: Advanced hepatocellular carcinoma (HCC) is a highly lethal disease, mainly due to the late stage at diagnosis and its rapid progression. Although patients with advanced HCC can choose targeted therapy or chemotherapy, overall, the treatment… read more here.
Keywords: neoantigen reactive; reactive cells; hcc patient; advanced hcc ... See more keywords
Neoantigen-Reactive T Cells: The Driving Force behind Successful Melanoma Immunotherapy
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DOI: 10.3390/cancers13236061
Abstract: Simple Summary Cancer immunotherapy is a revolutionary type of cancer therapy. It uses the patient’s own immune system to fight and potentially cure cancer. The first major breakthrough of immunotherapy came from successful clinical trials… read more here.
Keywords: tumor; cancer; melanoma immunotherapy; neoantigen reactive ... See more keywords