Harnessing neoantigen specific CD4 T cells for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5ri0220-603rr
Abstract: The goal of precision immunotherapy is to direct a patient's T cell response against the immunogenic mutations expressed on their tumors. Most immunotherapy approaches to‐date have focused on MHC class I‐restricted peptide epitopes by which… read more here.
Keywords: cd4 cells; immunotherapy; cells cancer; cancer immunotherapy ... See more keywords
In vitro induction of neoantigen-specific T cells in myelodysplastic syndrome, a disease with low mutational burden.
Sign Up to like & getrecommendations! Published in 2020 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2020.10.003
Abstract: Therapies that utilize immune checkpoint inhibition work by leveraging mutation-derived neoantigens and have shown greater clinical efficacy in tumors with higher mutational burden. Whether tumors with a low mutational burden are susceptible to neoantigen-targeted therapy… read more here.
Keywords: neoantigen specific; low mutational; specific cells; burden ... See more keywords
The mutant neoantigen specific T cell is a personalized immunotherapy in refractory solid tumour
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz253.054
Abstract: Abstract Background Immune checkpoint inhibitors are an important therapy. However, their essence is nonspecific and efficiency of single usage is not satisfactory. The mutant neoantigen specific T (Nas-T) cell, as an adoptive cell treatment, is… read more here.
Keywords: neoantigen; neoantigen specific; cell personalized; personalized immunotherapy ... See more keywords
Adenoviral-based vaccine promotes neoantigen-specific CD8+ T cell stemness and tumor rejection
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abo7604
Abstract: Upon chronic antigen exposure, CD8+ T cells become exhausted, acquiring a dysfunctional state correlated with the inability to control infection or tumor progression. In contrast, stem-like CD8+ T progenitors maintain the ability to promote and… read more here.
Keywords: cell; tumor; neoantigen specific; cd8 cells ... See more keywords
Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005328
Abstract: Background Merkel cell carcinoma (MCC) often responds to PD-1 pathway blockade, regardless of tumor-viral status (~80% of cases driven by the Merkel cell polyomavirus (MCPyV)). Prior studies have characterized tumor-specific T cell responses to MCPyV,… read more here.
Keywords: cell; response; cd4 cells; neoantigen specific ... See more keywords
Abstract 4055: Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in non-small cell lung cancer patients responding to atezolizumab treatment
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-4055
Abstract: There is strong evidence that immunotherapy-mediated tumor rejection can be driven by the reinvigoration of tumor-specific CD8+ T cells recognizing neoantigens derived from tumor somatic mutations (citations). Thus, it is possible that the relative abundance… read more here.
Keywords: specific cd8; cd8 cells; cd8; specific cells ... See more keywords
Abstract 3855: Kinetics of neoantigen-specific T cells in post-transplant relapse
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3855
Abstract: Introduction: Graft-versus-leukemia effect (GVL) underpins the curative mechanism of allogeneic stem cell transplantation (alloSCT) for acute leukemias. Donor-derived T cells can recognize various antigens, including human leukocyte antigen (HLA), minor-histocompatibility antigens (miHA), over-expressed antigens, or… read more here.
Keywords: relapse; specific cells; neoantigen specific; somatic mutations ... See more keywords
Single-cell clonal lineage tracing identifies the transcriptional program controlling the cell-fate decisions by neoantigen-specific CD8+ T cells.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-25-0203
Abstract: Neoantigen-specific T cells recognize tumor cells and are critical for cancer immunotherapies to be effective. However, the transcriptional program controlling the cell-fate decisions by neoantigen-specific T cells is incompletely understood. Here, using joint single-cell transcriptome… read more here.
Keywords: cell; specific cd8; neoantigen specific; cd8 cells ... See more keywords
Abstract B008: Rescuing neoantigen-specific CD8+ T-cell immunity from tumor- microenvironment-mediated immunosuppression in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Immunology Research"
DOI: 10.1158/2326-6074.tumimm24-b008
Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is highly lethal due to early metastasis and poor immunotherapy responses, driven by a desmoplastic tumor microenvironment (TME) and low immunogenicity. However, long-term human PDAC survivors exhibit higher neoantigen expression,… read more here.
Keywords: cd8; neoantigen specific; tumor; cell ... See more keywords
Divergent CD4+ T-Cell Fates Govern Relapse and Remission in B-Cell Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-205420
Abstract: Introduction: Eradicating measurable residual disease (MRD) in patients with B-ALL requires prolonged chemotherapy, allogeneic hematopoietic stem cell transplantation (HSCT) or newer approaches such as CART cells. However, relapse is common even after HSCT or CART… read more here.
Keywords: cd4 cells; neoantigen specific; bcr abl; cell ... See more keywords
Leukemia escapes immunity by imposing a type 1 regulatory program on neoantigen-specific CD4+ T cells.
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood.2024028194
Abstract: The significance of endogenous immune surveillance in acute lymphoblastic leukemia (ALL) remains controversial. Using clinical B-ALL samples and a novel mouse model, we show that neoantigen-specific CD4+ T-cells are induced to adopt type-1 regulatory (Tr1)… read more here.
Keywords: cd4 cells; neoantigen specific; specific cd4; leukemia ... See more keywords