Indication-specific tumor evolution and its impact on neoantigen targeting and biomarkers for individualized cancer immunotherapies
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DOI: 10.1136/jitc-2021-003001
Abstract: Background Individualized neoantigen-specific immunotherapy (iNeST) requires robustly expressed clonal neoantigens for efficacy, but tumor mutational heterogeneity, loss of neoantigen expression, and variable tissue sampling present challenges. It is assumed that clonal neoantigens are preferred targets… read more here.
Keywords: impact neoantigen; neoantigen targeting; clonal neoantigens; cancer ... See more keywords