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   Articles with "neoepitope" as a keyword



Abstract P3-03-26: Long-Read Nanopore Sequencing for the Identification of Gene Fusion-Derived Breast Cancer Neoepitopes

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recommendations! Published in 2025 at "Clinical Cancer Research"

DOI: 10.1158/1557-3265.sabcs24-p3-03-26

Abstract: Neoepitopes, which are unique HLA-binding peptides produced by cancer cells, are potential cancer-specific targets for T cell-based immunotherapies. However, there are ongoing challenges for the selection and prioritization of neoepitopes for therapeutics. First, next generation… read more here.

Keywords: cancer; breast cancer; long read; fusion derived ... See more keywords

The Potential and Challenges of Exploiting the Vast But Dynamic Neoepitope Landscape for Immunotherapy

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recommendations! Published in 2017 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2017.01113

Abstract: Somatic non-synonymous mutations in the DNA of tumor cells may result in the presentation of tumor-specific peptides to T cells. The recognition of these so-called neoepitopes now has been firmly linked to the clinical success… read more here.

Keywords: vast dynamic; exploiting vast; neoepitope; challenges exploiting ... See more keywords

Targeting the recurrent Rac1P29S neoepitope in melanoma with heterologous high-affinity T cell receptors

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recommendations! Published in 2023 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2023.1119498

Abstract: Recurrent neoepitopes are cancer-specific antigens common among groups of patients and therefore ideal targets for adoptive T cell therapy. The neoepitope FSGEYIPTV carries the Rac1P29S amino acid change caused by a c.85C>T missense mutation, which… read more here.

Keywords: cell; neoepitope; high affinity; rac1p29s ... See more keywords

Integrative Neoepitope Discovery in Glioblastoma via HLA Class I Profiling and AlphaFold2-Multimer

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recommendations! Published in 2025 at "Biomedicines"

DOI: 10.3390/biomedicines13112715

Abstract: Background/Objectives: Glioblastoma multiforme (GBM) is an aggressive primary brain tumor with limited therapeutic options. Neoantigen-based immunotherapy offers a promising avenue, but its efficacy primarily depends on the ability of somatic mutations to generate immunogenic peptides… read more here.

Keywords: hla class; hla; alphafold2 multimer; neoepitope ... See more keywords

Isolation of Neoantigen-Specific Human T Cell Receptors from Different Human and Murine Repertoires

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14071842

Abstract: Simple Summary T cell-based immunotherapy has achieved remarkable clinical responses in patients with cancer. Neoepitope-specific T cells can specifically recognize mutated tumor cells and have led to tumor regression in mouse models and clinical studies.… read more here.

Keywords: cell; tcr; neoepitope; specific tcrs ... See more keywords