The Potential and Challenges of Exploiting the Vast But Dynamic Neoepitope Landscape for Immunotherapy
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01113
Abstract: Somatic non-synonymous mutations in the DNA of tumor cells may result in the presentation of tumor-specific peptides to T cells. The recognition of these so-called neoepitopes now has been firmly linked to the clinical success… read more here.
Keywords: vast dynamic; exploiting vast; neoepitope; challenges exploiting ... See more keywords
Targeting the recurrent Rac1P29S neoepitope in melanoma with heterologous high-affinity T cell receptors
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1119498
Abstract: Recurrent neoepitopes are cancer-specific antigens common among groups of patients and therefore ideal targets for adoptive T cell therapy. The neoepitope FSGEYIPTV carries the Rac1P29S amino acid change caused by a c.85C>T missense mutation, which… read more here.
Keywords: cell; neoepitope; high affinity; rac1p29s ... See more keywords
Isolation of Neoantigen-Specific Human T Cell Receptors from Different Human and Murine Repertoires
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DOI: 10.3390/cancers14071842
Abstract: Simple Summary T cell-based immunotherapy has achieved remarkable clinical responses in patients with cancer. Neoepitope-specific T cells can specifically recognize mutated tumor cells and have led to tumor regression in mouse models and clinical studies.… read more here.
Keywords: cell; tcr; neoepitope; specific tcrs ... See more keywords