A non-functional neoepitope specific CD8+ T-cell response induced by tumor derived antigen exposure in vivo
Sign Up to like & getrecommendations! Published in 2019 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1553478
Abstract: ABSTRACT Cancer-associated mutations, mostly single nucleotide variations, can act as neoepitopes and prime targets for effective anti-cancer T-cell immunity. T cells recognizing cancer mutations are critical for the clinical activity of immune checkpoint blockade (ICB)… read more here.
Keywords: cd8; neoepitope specific; tumor; cell ... See more keywords
Isolation of Neoantigen-Specific Human T Cell Receptors from Different Human and Murine Repertoires
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071842
Abstract: Simple Summary T cell-based immunotherapy has achieved remarkable clinical responses in patients with cancer. Neoepitope-specific T cells can specifically recognize mutated tumor cells and have led to tumor regression in mouse models and clinical studies.… read more here.
Keywords: cell; tcr; neoepitope; specific tcrs ... See more keywords