The role of vascular smooth muscle cell membrane-bound thrombomodulin in neointima formation.
Sign Up to like & getrecommendations! Published in 2019 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2019.05.019
Abstract: BACKGROUND AND AIMS Thrombomodulin (TM) is an endothelial cell membrane-bound anticoagulant protein expressed in normal arteries. After vascular injury, medial and neointimal smooth muscle cells (SMCs) exhibit large amounts of TM. The purpose of this… read more here.
Keywords: neointima formation; phenotype; smc; cell membrane ... See more keywords
Near-infrared -triggered release of tirofiban from nanocarriers for the inhibition of platelet integrin αIIbβ3 to decrease early-stage neointima formation.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr00555j
Abstract: Platelets play an important role in the early stage of arterial remodeling after injury. Integrin GPIIb/IIIα (αIIbβ3) regulates platelet activation in the inside-out and outside-in signaling pathways. The use of tirofiban, an integrin αIIbβ3 inhibitor,… read more here.
Keywords: neointima formation; integrin iib; platelet; iib ... See more keywords
Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac190
Abstract: AIMS Endothelial-to-mesenchymal transition (EndMT) is a fundamental process in vascular remodeling. However, the precise regulatory mechanism of vascular remodeling during neointima formation and source of neointima cells are not entirely understood. METHODS AND RESULTS To… read more here.
Keywords: endmt; cell; mesenchymal transition; endothelial mesenchymal ... See more keywords
A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy
Sign Up to like & getrecommendations! Published in 2021 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehab140
Abstract: Abstract Aims In-stent restenosis is a complication after coronary stenting associated with morbidity and mortality. Here, we sought to investigate the molecular processes underlying neointima formation and to identify new treatment and prevention targets. Methods… read more here.
Keywords: neointima identifies; identifies novel; formation; proteomic atlas ... See more keywords
P4143IL-6 production in the vascular adventitia and adventitia-media-crosstalk in neointima formation
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz745.0715
Abstract: The aim of this study was to analyze the impact of the adventitial layer on vascular remodeling processes and to define the underlying cellular mechanisms. Morphometric analysis of human coronary arteries and of murine femoral… read more here.
Keywords: adventitial layer; proliferation; formation; adventitia ... See more keywords
BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad120
Abstract: Abstract The transcription factor BTB and CNC homology 1(BACH1) has been linked to coronary artery disease risk by human genome-wide association studies, but little is known about the role of BACH1 in vascular smooth muscle… read more here.
Keywords: chromatin accessibility; vascular smooth; bach1; smooth muscle ... See more keywords
Parent artery-initiated and stent-mediated neointima formation in a rat saccular side wall model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurointerventional Surgery"
DOI: 10.1136/neurintsurg-2021-018297
Abstract: Background Unlike clipping that forms an immediate barrier of blood flow into intracranial aneurysms, endovascular treatments rely on thrombus organization and neointima formation. Therefore, a continuous endothelial cell layer is crucial to prevent blood flow… read more here.
Keywords: wall; parent artery; stent; formation ... See more keywords
Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.116.308717
Abstract: Objective— Aberrant proliferation of smooth muscle cells (SMC) in response to injury induces pathological vascular remodeling during atherosclerosis and neointima formation. Telomerase is rate limiting for tissue renewal and cell replication; however, the physiological role… read more here.
Keywords: silencing e2f1; telomerase reverse; formation; tert ... See more keywords
Protective role of cytochrome c oxidase 5A (COX5A) against mitochondrial disorder and oxidative stress in VSMC phenotypic modulation and neointima formation.
Sign Up to like & getrecommendations! Published in 2023 at "Current vascular pharmacology"
DOI: 10.2174/1570161121666230315142507
Abstract: BACKGROUND The pathological role of cytochrome c oxidase 5A (COX5A) in vascular neointima formation remains unknown. AIM This study aims to investigate the role of COX5A on Platelet-derived growth factor BB (PDGF-BB)-mediated smooth muscle phenotypic… read more here.
Keywords: role; phenotypic modulation; cox5a; neointima formation ... See more keywords
A proteomics analysis of neointima formation on decellularized vascular grafts reveals regenerative alterations in protein signature running head: Proteomics analysis of neointima formation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.894956
Abstract: Background: Neointima formation contributes to vascular grafts stenosis and thrombosis. It is a complex reaction that plays a significant role in the performance of vascular grafts. Despite its critical implications, little is known about the… read more here.
Keywords: neointima formation; vascular grafts; analysis neointima; formation ... See more keywords
Empagliflozin prevents neointima formation by impairing smooth muscle cell proliferation and accelerating endothelial regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.956041
Abstract: Background Empagliflozin, an inhibitor of the sodium glucose co-transporter 2 (SGLT2) and developed as an anti-diabetic agent exerts additional beneficial effects on heart failure outcomes. However, the effect of empagliflozin on vascular cell function and… read more here.
Keywords: empagliflozin; cell; proliferation; smooth muscle ... See more keywords