Protective mechanism of ferulic acid against neomycinâinduced ototoxicity in zebrafish
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DOI: 10.1002/tox.23707
Abstract: Ototoxicity refers to damage of sensory hair cells and functional hearing impairment following aminoglycosides exposure. Previously, we have determined that ferulic acid (FA) protected hair cells against serial concentrations of neomycinâinduced ototoxic damage. The aim… read more here.
Keywords: transgenic zebrafish; hair cells; mechanism; ferulic acid ... See more keywords
Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage
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DOI: 10.3389/fcell.2020.00712
Abstract: Aminoglycoside-induced hair cell (HC) loss is one of the most important causes of hearing loss. After entering the inner ear, aminoglycosides induce the production of high levels of reactive oxygen species (ROS) that subsequently activate… read more here.
Keywords: neomycin induced; citicoline; hcs; hair ... See more keywords
The Ameliorative Effect of JNK Inhibitor D-JNKI-1 on Neomycin-Induced Apoptosis in HEI-OC1 Cells
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DOI: 10.3389/fnmol.2022.824762
Abstract: Aminoglycosides can cause ototoxicity and lead to hair cell damage. Neomycin-induced ototoxicity is related to increased production of reactive oxygen species (ROS) and triggering hair cell apoptosis. The c-Jun-N-terminal kinase (JNK) pathway plays an essential… read more here.
Keywords: cell; apoptosis; jnk; hei oc1 ... See more keywords
Pitavastatin protects against neomycin-induced ototoxicity through inhibition of endoplasmic reticulum stress
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DOI: 10.3389/fnmol.2022.963083
Abstract: Irreversible injury to inner ear hair cells induced by aminoglycoside antibiotics contributes to the formation of sensorineural hearing loss. Pitavastatin (PTV), a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, has been reported to exert neuroprotective effects. However,… read more here.
Keywords: endoplasmic reticulum; reticulum stress; ptv; neomycin induced ... See more keywords