Evaluation of neonatal brain myelination using the T1‐ and T2‐weighted MRI ratio
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.25570
Abstract: To validate the T1‐ and T2‐weighted (T1w/T2w) MRI ratio technique in evaluating myelin in the neonatal brain. read more here.
Keywords: mri ratio; evaluation neonatal; neonatal brain; brain myelination ... See more keywords
Survey of Acoustic Output in Neonatal Brain Protocols
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.27656
Abstract: Auditory and non‐auditory safety concerns associated with the appreciable sound levels inherent to magnetic resonance imaging (MRI) procedures exist for neonates. However, current gaps in knowledge preclude making an adequate risk assessment. read more here.
Keywords: brain protocols; output neonatal; neonatal brain; survey acoustic ... See more keywords
Clinical RNA sequencing confirms compound heterozygous intronic variants in RYR1 in a patient with congenital myopathy, respiratory failure, neonatal brain hemorrhage, and d-transposition of the great arteries.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular genetics & genomic medicine"
DOI: 10.1002/mgg3.1804
Abstract: BACKGROUND Defects in the RYR1 (OMIM#180901) gene lead to Ryanodine receptor type 1-related myopathies (RYR1-RM); the most common subgroup of congenital myopathies. METHODS Congenital myopathy presents a diagnostic challenge due to the need for multiple… read more here.
Keywords: congenital myopathy; rna sequencing; neonatal brain; intronic variants ... See more keywords
In vivo T1 mapping of neonatal brain tissue at 64 mT
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29509
Abstract: Ultralow‐field (ULF) point‐of‐care MRI systems allow image acquisition without interrupting medical provision, with neonatal clinical care being an important potential application. The ability to measure neonatal brain tissue T1 is a key enabling technology for… read more here.
Keywords: brain; brain tissue; vivo mapping; mapping neonatal ... See more keywords
Pharmacologic Prevention and Treatment of Neonatal Brain Injury.
Sign Up to like & getrecommendations! Published in 2019 at "Clinics in perinatology"
DOI: 10.1016/j.clp.2019.02.006
Abstract: Neonatal brain injury (NBI) remains a major contributor to neonatal mortality and long-term neurodevelopmental morbidity. Although therapeutic hypothermia is the only proven treatment to minimize brain injury caused by neonatal encephalopathy in term neonates, it… read more here.
Keywords: treatment; preterm neonates; brain injury; neonatal brain ... See more keywords
A review on automatic fetal and neonatal brain MRI segmentation
Sign Up to like & getrecommendations! Published in 2018 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2017.06.074
Abstract: ABSTRACT In recent years, a variety of segmentation methods have been proposed for automatic delineation of the fetal and neonatal brain MRI. These methods aim to define regions of interest of different granularity: brain, tissue… read more here.
Keywords: brain mri; fetal neonatal; segmentation; neonatal brain ... See more keywords
Prolonged ketamine exposure induces increased activity of the GluN2B-containing N-methyl-d-aspartate receptor in the anterior cingulate cortex of neonatal rats.
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2017.07.005
Abstract: Ketamine is a commonly used anesthetic among pediatric patients due to its high efficacy. However, it has been demonstrated by several preclinical studies that, widespread accelerated programmed death of neurons (neuroapoptosis) occurs due to prolonged… read more here.
Keywords: methyl aspartate; ketamine; exposure; glun2b containing ... See more keywords
Inflammatory modulation of the associations between prenatal maternal depression and neonatal brain
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-0774-0
Abstract: Inflammatory signaling has a role in sensing intrauterine environment, which may be moderators in altering fetal brain development upon maternal environment. This study integrated cytokine transcriptome of post-mortem fetal brains, neonatal brain imaging and genetic… read more here.
Keywords: maternal depression; neonatal brain; brain; prenatal maternal ... See more keywords
Shedding light on the neonatal brain: probing cerebral hemodynamics by diffuse optical spectroscopic methods
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15995-1
Abstract: Investigating the cerebral physiology of healthy term newborns’ brains is important for better understanding perinatal brain injuries, of which the most common etiologies are hypoxia and ischemia. Hence, cerebral blood flow and cerebral oxygenation are… read more here.
Keywords: cerebral hemodynamics; diffuse optical; neonatal brain; spectroscopy ... See more keywords
Mitochondrial dynamics in the neonatal brain – a potential target following injury?
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20211696
Abstract: Abstract The impact of birth asphyxia and its sequelae, hypoxic–ischaemic (HI) brain injury, is long-lasting and significant, both for the infant and for their family. Treatment options are limited to therapeutic hypothermia, which is not… read more here.
Keywords: brain injury; neonatal brain; injury; mitochondrial dynamics ... See more keywords
Wnt family member 1 (Wnt1) overexpression-induced M2 polarization of microglia alleviates inflammation-sensitized neonatal brain injuries
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2074767
Abstract: ABSTRACT Intrauterine infection induces inflammation-mediated microglial activation and brain injury. This study aimed to explore the regulatory mechanism of Wnt family member 1 (Wnt1) in intrauterine infection-mediated microglial polarization. The cell counting kit-8 (CCK-8) assay… read more here.
Keywords: inflammation; brain; overexpression; neonatal brain ... See more keywords