TCR repertoire analysis reveals phosphoantigen‐induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0120-427rr
Abstract: The Vγ9Vδ2 T cell subset is the major γδ T cell subset in human peripheral blood and has the unique ability to contribute to immune surveillance by detecting pyrophosphorylated metabolites of isoprenoid synthesis, termed phosphoantigens… read more here.
Keywords: pag; tcr repertoire; neonatal cells; proliferation ... See more keywords
γδTCR-independent origin of neonatal γδ T cells prewired for IL-17 production.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2019.04.011
Abstract: A classical view of T cell lineages consists of two major clades of T cells expressing either the αβ or γδ T cell receptor (TCR). However, genome-wide assessments indicate molecular clusters segregating T cell subsets… read more here.
Keywords: independent origin; origin neonatal; neonatal cells; cells prewired ... See more keywords
Neonatal T Cells: A Reinterpretation.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-091319-083608
Abstract: Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or defective. However, recent studies prompt a reinterpretation of the functions of neonatal T cells. Rather than a population of cells always falling short of… read more here.
Keywords: neonatal cells; review; cells reinterpretation; immunology ... See more keywords