Mechanisms of Neonatal Heart Regeneration
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DOI: 10.1007/s11886-020-01282-5
Abstract: Purpose of Review This review provides an overview of the molecular mechanisms underpinning the cardiac regenerative capacity during the neonatal period and the potential targets for developing novel therapies to restore myocardial loss. Recent Findings… read more here.
Keywords: cardiology; regeneration; neonatal heart; mechanisms neonatal ... See more keywords
A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration
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DOI: 10.1016/j.cell.2018.12.023
Abstract: Collateral arteries are an uncommon vessel subtype that can provide alternate blood flow to preserve tissue following vascular occlusion. Some patients with heart disease develop collateral coronary arteries, and this correlates with increased survival. However,… read more here.
Keywords: heart; artery; neonatal heart; collateral artery ... See more keywords
LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17311
Abstract: The neonatal heart can efficiently regenerate within a short period after birth, whereas the adult mammalian heart has extremely limited capacity to regenerate. The molecular mechanisms underlying neonatal heart regeneration remain elusive. Here, we revealed… read more here.
Keywords: heart; cardiomyocyte proliferation; neonatal heart; heart regeneration ... See more keywords
Abstract 724: Neonatal Heart Regeneration Preserves Native Ventricular Biomechanical Properties After Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.724
Abstract: Introduction: Neonatal mice exhibit natural heart regeneration after myocardial infarction (MI) until postnatal day 7 (P7). Whether this regenerated muscle is similar biomechanically to native myocardium remains unknown. We hypothesized that neonatal heart regeneration preserves… read more here.
Keywords: biomechanical properties; myocardial infarction; heart regeneration; neonatal heart ... See more keywords