Maternal antibiotic exposure disrupts microbiota and exacerbates hyperoxia-induced lung injury in neonatal mice
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DOI: 10.1038/s41390-020-01335-z
Abstract: Background Perinatal antibiotic treatment alters intestinal microbiota and augments hyperoxia-induced lung injury in mice offspring. The effect of maternal antibiotic treatment (MAT) during pregnancy on the lung microbiota and its relationship with lung injury remains… read more here.
Keywords: hyperoxia induced; neonatal hyperoxia; hyperoxia; lung injury ... See more keywords
Neonatal hyperoxia exposure induces aortic biomechanical alterations and cardiac dysfunction in juvenile rats
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DOI: 10.14814/phy2.14334
Abstract: Supplemental oxygen (O2) therapy in preterm infants impairs lung development, but the impact of O2 on long‐term systemic vascular structure and function has not been well‐explored. The present study tested the hypothesis that neonatal O2… read more here.
Keywords: function; biomechanical alterations; hyperoxia exposure; neonatal hyperoxia ... See more keywords
Gelsolin Attenuates Neonatal Hyperoxia-Induced Inflammatory Responses to Rhinovirus Infection and Preserves Alveolarization
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DOI: 10.3389/fimmu.2022.792716
Abstract: Prematurity and bronchopulmonary dysplasia (BPD) increase the risk of asthma later in life. Supplemental oxygen therapy is a risk factor for chronic respiratory symptoms in infants with BPD. Hyperoxia induces cell injury and release of… read more here.
Keywords: hyperoxia induced; gelsolin; hyperoxic balf; neonatal hyperoxia ... See more keywords
Lung-Specific Extracellular Superoxide Dismutase Improves Cognition of Adult Mice Exposed to Neonatal Hyperoxia
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DOI: 10.3389/fmed.2018.00334
Abstract: Lung and brain development is often altered in infants born preterm and exposed to excess oxygen, and this can lead to impaired lung function and neurocognitive abilities later in life. Oxygen-derived reactive oxygen species and… read more here.
Keywords: sod; neonatal hyperoxia; mice exposed; mice ... See more keywords