White matter injury in the neonatal hypoxic‐ischemic brain and potential therapies targeting microglia
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24761
Abstract: Neonatal hypoxic–ischemic (H‐I) injury, which mainly causes neuronal damage and white matter injury (WMI), is among the predominant causes of infant morbidity (cerebral palsy, cognitive and persistent motor disabilities) and mortality. Disruptions to the oxygen… read more here.
Keywords: matter injury; hypoxic ischemic; brain; neonatal hypoxic ... See more keywords
Intrapartum fetal monitoring and perinatal risk factors of neonatal hypoxic–ischemic encephalopathy
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-020-05757-2
Abstract: Neonatal hypoxic–ischemic encephalopathy (HIE) in term infants, is a major cause of neonatal mortality and severe neurologic disability. To identify in labor fetal monitoring characteristic patterns and perinatal factors associated with neonatal HIE. Single-center retrospective… read more here.
Keywords: hypoxic ischemic; ischemic encephalopathy; monitoring; hie ... See more keywords
δ-Opioid Receptor-Nrf-2-Mediated Inhibition of Inflammatory Cytokines in Neonatal Hypoxic-Ischemic Encephalopathy
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1452-7
Abstract: Neonatal hypoxic-ischemic encephalopathy (HIE) causes serious neurological disability; there are, however, currently few promising therapies for it. We have recently shown that δ-opioid receptor (DOR) is neuroprotective by downregulating TNF-α. Since hypoxia-ischemia (HI) triggers a… read more here.
Keywords: opioid receptor; hypoxic ischemic; dor; inflammatory ... See more keywords
IRF5 Signaling in Phagocytes Is Detrimental to Neonatal Hypoxic Ischemic Encephalopathy
Sign Up to like & getrecommendations! Published in 2020 at "Translational Stroke Research"
DOI: 10.1007/s12975-020-00832-x
Abstract: Immune responses to neonatal hypoxic ischemic encephalopathy (HIE) exacerbate brain injury. Phagocytes, including microglia, play a central role in the immune response, but how the activation of phagocytes is regulated remains elusive. Previously, we have… read more here.
Keywords: irf5; hypoxic ischemic; ischemic encephalopathy; neonatal hypoxic ... See more keywords
Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.02.006
Abstract: Acute hypothermia treatment (HT) is the only clinically established intervention following neonatal hypoxic-ischemic brain injury. However, almost half of all cooled infants still die or suffer from long-lasting neurological impairments. Regenerative therapies, such as mesenchymal… read more here.
Keywords: hypoxic ischemic; brain; msc; neonatal hypoxic ... See more keywords
Deficits in ultrasonic vocalization development and production following neonatal hypoxic ischemic insult
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.111931
Abstract: Neonatal hypoxic ischemia encephalopathy (HIE) leads to major deficits in language development. While clinically there is a known correlation in the degree of HIE injury and subsequent language disability, there are no treatments beyond speech… read more here.
Keywords: production; deficits ultrasonic; ultrasonic vocalization; neonatal hypoxic ... See more keywords
Lycium ruthenicum Murr polysaccharide protects cortical neurons against oxygen-glucose deprivation/reperfusion in neonatal hypoxic-ischemic encephalopathy.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.04.122
Abstract: Neonatal hypoxic-ischemic encephalopathy (HIE) is a complex condition that remains the leading cause of mortality and morbidity among infants. Polysaccharide has been reported to possess diverse biological activities, however, the neuro-protective activity of polysaccharide isolated… read more here.
Keywords: ogd induced; hypoxic ischemic; lycium ruthenicum; neonatal hypoxic ... See more keywords
Incidence, Intrapartum Risk Factors, and Prognosis of Neonatal Hypoxic-Ischemic Encephalopathy Among Infants Born at 35 Weeks Gestation or More.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC"
DOI: 10.1016/j.jogc.2020.04.020
Abstract: INTRODUCTION Neonatal hypoxic-ischemic encephalopathy (HIE) is associated with neonatal mortality, acute neurological injury, and long-term neurodevelopmental disabilities; however, the association between intrapartum factors and HIE remains unclear. METHODS This population-based cohort study used linked obstetrical… read more here.
Keywords: among infants; gestation; weeks gestation; hypoxic ischemic ... See more keywords
Ketogenic Diet for Neonatal Hypoxic-Ischemic Encephalopathy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00609
Abstract: The prevalence of neonatal hypoxic-ischemic encephalopathy (HIE), a devastating neurological injury, is increasing; thus, effective treatments and preventions are urgently needed. The underlying pathology of HIE remains unclear; recent research has focused on elucidating key… read more here.
Keywords: hypoxic ischemic; hie; neonatal hypoxic; ischemic encephalopathy ... See more keywords
Effects of a potassium channel opener on brain injury and neurologic outcomes in an animal model of neonatal hypoxic-ischemic injury
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric research"
DOI: 10.1038/s41390-019-0734-8
Abstract: Background Hypoxia–ischemia (HI) is the most common cause of brain injury in newborns and the survivors often develop cognitive and sensorimotor disabilities that undermine the quality of life. In the current study, we examined the… read more here.
Keywords: animal model; hypoxic ischemic; neonatal hypoxic; brain injury ... See more keywords
MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-019-0257-6
Abstract: Neuroinflammation is a major contributor to secondary neuronal injury that accounts for a significant proportion of final brain cell loss in neonatal hypoxic-ischemic encephalopathy (HIE). However, the immunological mechanisms that underlie HIE remain unclear. MicroRNA-210… read more here.
Keywords: hypoxic ischemic; neuroinflammation; mir 210; neonatal hypoxic ... See more keywords