Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia
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DOI: 10.1055/s-0038-1646924
Abstract: Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin α2β1, or to defects in downstream… read more here.
Keywords: neonatal platelets; term; clec; gpvi clec ... See more keywords
Assessment of neonatal, cord, and adult platelet granule trafficking and secretion
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DOI: 10.1080/09537104.2019.1573314
Abstract: Abstract Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole… read more here.
Keywords: neonatal platelets; neonatal cord; adult platelets; cord ... See more keywords
CAPN1 (Calpain1)-Dependent Cleavage of STIM1 (Stromal Interaction Molecule 1) Results in an Enhanced SOCE (Store-Operated Calcium Entry) in Human Neonatal Platelets
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DOI: 10.1161/atvbaha.122.318015
Abstract: Background: Altered intracellular Ca2+ homeostasis in neonatal platelets has been previously reported. This study aims to examine the changes in the Ca2+ entry through the store-operated calcium entry (SOCE) mechanism in neonatal platelets. Methods: Human… read more here.
Keywords: capn1; stromal interaction; ca2; neonatal platelets ... See more keywords
Transfusion of Adult, but Not Neonatal, Platelets Promotes Monocyte Trafficking in Neonatal Mice
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DOI: 10.1161/atvbaha.122.318162
Abstract: Background: Thrombocytopenia is common in preterm neonates. Platelet transfusions are sometimes given to thrombocytopenic neonates with the hope of reducing the bleeding risk, however, there are little clinical data to support this practice, and platelet… read more here.
Keywords: adult; adult neonatal; neonatal platelets; mice ... See more keywords