Comparison of Neonatal and Adult Fibrin Clot Properties between Porcine and Human Plasma
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DOI: 10.1097/aln.0000000000003165
Abstract: Background: Recent studies suggest that adult-specific treatment options for fibrinogen replacement during bleeding may be less effective in neonates. This is likely due to structural and functional differences found in the fibrin network between adults… read more here.
Keywords: microscopy; adult; porcine human; neonatal porcine ... See more keywords
Functional Maturation and In Vitro Differentiation of Neonatal Porcine Islet Grafts
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DOI: 10.1097/tp.0000000000002354
Abstract: Background There is a strong rationale to pursue the use of neonatal porcine islets (NPIs) as an unlimited source of islets for clinical xenotransplantation. Because NPIs are composed of immature insulin producing beta (ß) cells… read more here.
Keywords: neonatal porcine; vitro differentiation; differentiation; cell ... See more keywords
Early immune mechanisms of neonatal porcine islet xenograft rejection
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DOI: 10.1111/xen.12546
Abstract: Neonatal pigs have the potential to provide an inexhaustible source of islets for the treatment of type 1 diabetes. However, the immunological barriers to islet xenotransplantation still need to be overcome. A better understanding of… read more here.
Keywords: neonatal porcine; early immune; rejection; porcine islet ... See more keywords
Co‐transplantation of human adipose‐derived mesenchymal stem cells with neonatal porcine islets within a prevascularized subcutaneous space augments the xenograft function
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DOI: 10.1111/xen.12581
Abstract: Cell transplantation has been widely recognized as a curative treatment strategy for variety of diseases including type I diabetes (T1D). Broader patient inclusion for this therapeutic option is restricted by a limited supply of healthy… read more here.
Keywords: neonatal porcine; porcine islets; transplantation; stem cells ... See more keywords
Xenotransplantation of neonatal porcine bone marrow–derived mesenchymal stem cells improves diabetic wound healing by promoting angiogenesis and lymphangiogenesis
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DOI: 10.1111/xen.12739
Abstract: Some clinical trials have shown the usefulness of stem cell therapy for diabetic foot ulcers. However, the donor supply is limited, and the process is time consuming and expensive. This study assessed the therapeutic effects… read more here.
Keywords: neonatal porcine; bone marrow; marrow derived; xenotransplantation ... See more keywords
No evidence of enteric viral involvement in the new neonatal porcine diarrhoea syndrome in Danish pigs
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DOI: 10.1186/s12917-017-1239-5
Abstract: BackgroundThe aim of this study was to investigate whether the syndrome New Neonatal Porcine Diarrhoea Syndrome (NNPDS) is associated with a viral aetiology. Four well-managed herds experiencing neonatal diarrhoea and suspected to be affected by… read more here.
Keywords: neonatal porcine; diarrhoea; porcine; diarrhoea syndrome ... See more keywords
Bioabsorption of Subcutaneous Nanofibrous Scaffolds Influences the Engraftment and Function of Neonatal Porcine Islets
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DOI: 10.3390/polym14061120
Abstract: The subcutaneous space is currently being pursued as an alternative transplant site for ß-cell replacement therapies due to its retrievability, minimally invasive procedure and potential for graft imaging. However, implantation of ß-cells into an unmodified… read more here.
Keywords: porcine islets; function; neonatal porcine; plga ... See more keywords