Using a neonatal rat model to explore the therapeutic potential of coenzyme Q10 in prematurity under hyperoxia
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23499
Abstract: Hyperoxia, is often used in preterm supportive care, leading to high oxygen exposure in neonates. Coenzyme Q10 (CoQ10) is a free radical scavenger that has been studied in older children but never be investigated for… read more here.
Keywords: neonatal rat; oxidative stress; coenzyme q10; using neonatal ... See more keywords
PKC delta activation increases neonatal rat retinal cells survival in vitro: Involvement of neurotrophins and M1 muscarinic receptors.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.193
Abstract: Protein kinase C (PKC) is a family of serine/threonine kinases related to several phenomena as cell proliferation, differentiation and survival. Our previous data demonstrated that treatment of axotomized neonatal rat retinal cell cultures for 48 h… read more here.
Keywords: delta activation; m1r; activation; neonatal rat ... See more keywords
Hydrogen sulfide protects neonatal rat medulla oblongata against prenatal cigarette smoke exposure via anti-oxidative and anti-inflammatory effects.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2017.12.009
Abstract: We previously demonstrated that hydrogen sulfide (H2S) protected neonatal rat medulla oblongata from prenatal cigarette smoke exposure (CSE) via anti-apoptotic effect. The present work further investigated the involvement of anti-oxidative and anti-inflammatory effects of H2S… read more here.
Keywords: rat medulla; medulla; medulla oblongata; cse ... See more keywords
Lentiviral transduction of neonatal rat ventricular myocytes preserves ultrastructural features of genetically modified cells.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.07.015
Abstract: Preserving morphological features that are important for cell function and structure is a critical parameter for in vitro experiments with rat cardiomyocytes. Lentiviral vectors are commonly used as gene transfer tool because of its high… read more here.
Keywords: features genetically; rat ventricular; ventricular myocytes; neonatal rat ... See more keywords
Myeloperoxidase causes both arrhythmogenic structural and electrical remodelling in neonatal rat ventricular myocyte monolayers
Sign Up to like & getrecommendations! Published in 2023 at "Europace"
DOI: 10.1093/europace/euad122.016
Abstract: Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): This study was supported by Netherlands Organization for Health Research and Development Background Myeloperoxidase (MPO), an enzyme most abundantly… read more here.
Keywords: ventricular myocyte; neonatal rat; control; mpo incubated ... See more keywords
Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia-Ischemia in Neonatal Rat Brains
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/8848015
Abstract: Hypoxia-ischemia (HI) in an immature brain results in energy depletion and excessive glutamate release resulting in excitotoxicity and oxidative stress. An increase in reactive oxygen species (ROS) production induces apoptotic processes resulting in neuronal death.… read more here.
Keywords: hypoxia ischemia; mglur2; application; neonatal rat ... See more keywords
Cerebral microbleeds in a neonatal rat model
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0171163
Abstract: Background In adult humans, cerebral microbleeds play important roles in neurodegenerative diseases but in neonates, the consequences of cerebral microbleeds are unknown. In rats, a single pro-angiogenic stimulus in utero predisposes to cerebral microbleeds after… read more here.
Keywords: pro angiogenic; microbleeds neonatal; angiogenic stimuli; neonatal rat ... See more keywords
Neonatal Rat Heart Response to Pressure Overload.
Sign Up to like & getrecommendations! Published in 2017 at "International heart journal"
DOI: 10.1536/ihj.17-006
Abstract: H eart failure is caused by myocyte loss secondary to necrosis and/or apoptosis due to injury or excess workload, and is further complicated by adverse remodeling. Recently, there is increasing evidence refuting the traditional notion… read more here.
Keywords: heart; response pressure; neonatal rat; rat heart ... See more keywords
Chronic Lactate Exposure Decreases Mitochondrial Function by Inhibition of Fatty Acid Uptake and Cardiolipin Alterations in Neonatal Rat Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.809485
Abstract: Introduction Lactate is an important signaling molecule with autocrine, paracrine and endocrine properties involved in multiple biological processes including regulation of gene expression and metabolism. Levels of lactate are increased chronically in diseases associated with… read more here.
Keywords: chronic lactate; neonatal rat; lactate; cardiolipin ... See more keywords
Sinapic Acid Inhibits Cardiac Hypertrophy via Activation of Mitochondrial Sirt3/SOD2 Signaling in Neonatal Rat Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9111163
Abstract: Sinapic acid (SA) is a naturally occurring phenolic compound with antioxidant properties. It also has a wide range of pharmacological properties, such as anti-inflammatory, anticancer, and hepatoprotective properties. The present study aimed to evaluate the… read more here.
Keywords: cardiac hypertrophy; sinapic acid; hypertrophy; neonatal rat ... See more keywords
Cellular Mechanisms of Angiogenesis in Neonatal Rat Models of Retinal Neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20194759
Abstract: Νeuronal and glial cells play an important role in the development of vasculature in the retina. In this study, we investigated whether re-vascularization occurs in retinal neurodegenerative injury models. To induce retinal injury, N-methyl-D-aspartic acid… read more here.
Keywords: vascularization; angiogenesis neonatal; neonatal rat; retinal neurodegeneration ... See more keywords