Sevoflurane neurotoxicity in neonatal rats is related to an increase in the GABAAR α1/GABAAR α2 ratio
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24118
Abstract: Exposure of neonatal rat to sevoflurane leads to neurodegeneration and deficits of spatial learning and memory in adulthood. However, the underlying mechanisms remain unclear. The type A γ‐aminobutyric acid receptor (GABAAR) is a target receptor… read more here.
Keywords: gabaar gabaar; exposure; expression; gabaar ... See more keywords
Folic acid alleviates jaundice of phenylhydrazine (PHA)-induced neonatal rats by reducing Lys-homocysteinylation of albumin.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-021-09602-3
Abstract: Neonatal jaundice is a common symptom that occurs in neonates during the first month of their life and is generally divided into physiological and pathological subtypes. In serious cases, pathological neonatal jaundice frequently shows complications… read more here.
Keywords: folic acid; hcy; jaundice; neonatal jaundice ... See more keywords
Methionine attenuates the intensity of rheumatoid arthritis by downregulating NF-κB and iNOS expression in neonatal rats
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DOI: 10.1007/s13205-018-1311-2
Abstract: The present study investigated the anti-arthritic effects of methionine in neonatal rats. Rats were divided into four groups, with six rats in each group. The rats were administered methionine (150- or 300-mg/kg body weight) orally… read more here.
Keywords: methionine; group; expression; rheumatoid arthritis ... See more keywords
MicroRNA-96 is responsible for sevoflurane-induced cognitive dysfunction in neonatal rats via inhibiting IGF1R
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.09.001
Abstract: Sevoflurane is an experimental potent yet volatile anesthesia agent characterized by a low blood/gas partition coefficient. However, exposure to sevoflurane in neonatal mice has been speculated to result in learning deficits and abnormal social behavior.… read more here.
Keywords: dysfunction neonatal; mir; cognitive dysfunction; neonatal rats ... See more keywords
TLR4 inhibition ameliorates mesencephalic substantia nigra injury in neonatal rats exposed to lipopolysaccharide via regulation of neuro-immunity
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.09.012
Abstract: Dopaminergic neurons play a key role in motor function of the extrapyramidal system. Previous studies have shown that septic neonates may have cognitive dysfunction in later life. Toll-like receptor 4 (TLR4) is a transmembrane protein… read more here.
Keywords: exposed lipopolysaccharide; inhibition; rats exposed; dopaminergic neurons ... See more keywords
Synaptic structure and alterations in the hippocampus in neonatal rats exposed to lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134364
Abstract: Synaptic structure integrity plays a key role in learning and memory. Previous studies have shown that there is cognitive dysfunction in septic neonates in later life. In this study, intraperitoneal injection of lipopolysaccharide (LPS) in… read more here.
Keywords: lps injection; synaptic structure; hippocampus; expression ... See more keywords
Telomerase reverse transcriptase (TERT) promotes neurogenesis after hypoxic-ischemic brain damage in neonatal rats
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2022.2056339
Abstract: ABSTRACT Objective Neonatal hypoxic-ischemic encephalopathy (HIE) endangers quality of life in children, and curative attempts are rarely effective. Neurogenesis plays an important role in neural repair following brain damage. This study aimed to investigate the… read more here.
Keywords: brain damage; neonatal rats; hypoxic ischemic; tert ... See more keywords
The effects of bosentan on hyperoxia‐induced lung injury in neonatal rats
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DOI: 10.1111/ped.14013
Abstract: Bronchopulmonary dysplasia (BPD) remains an important cause of morbidity and mortality in premature infants. There is currently no proven effective treatment modality for BPD, and inflammation and oxidative injury play an important role in the… read more here.
Keywords: effects bosentan; hyperoxia induced; induced lung; lung injury ... See more keywords
Corrigendum to “Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation”
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/8695089
Abstract: [This corrects the article DOI: 10.1155/2019/5406468.]. read more here.
Keywords: spermidine prevents; injury neonatal; heart injury; corrigendum spermidine ... See more keywords
Geraniol Ameliorates Sepsis in Neonatal Rats by Regulating Calprotectin and Inflammatory Response
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DOI: 10.12691/jfnr-9-11-1
Abstract: Sepsis is characterized by systemic infection that causes multiple organ dysfunction and is associated with a high mortality rate in the paediatric intensive care unit. In the present study, we investigated the effect of geraniol… read more here.
Keywords: sepsis neonatal; sepsis; neonatal rats; sepsis rats ... See more keywords
Effects of benzo(a)pyrene exposure on the ATPase activity and calcium concentration in the hippocampus of neonatal rats.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of occupational medicine and environmental health"
DOI: 10.13075/ijomeh.1896.00744
Abstract: OBJECTIVES To investigate whether postnatal benzo(a)pyrene (B(a)P) exposure caused the impairments on the process of neurodevelopment and the alteration in the calcium medium in the neonatal rats. MATERIAL AND METHODS Eighty neonatal Sprague Dawley (SD)… read more here.
Keywords: hippocampus; atpase; exposure; calcium ... See more keywords