Fc engineered anti‐virus therapeutic human IgG1 expressed in plants with altered binding to the neonatal Fc receptor
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202300552
Abstract: Production of therapeutic monoclonal antibody (mAb) in transgenic plants has several advantages such as large‐scale production and the absence of pathogenic animal contaminants. However, mAb with high mannose (HM) type glycans has shown a faster… read more here.
Keywords: mabpk so57; virus therapeutic; neonatal receptor; so57 ... See more keywords
Neonatal Fc receptor blockade as emerging therapy in diseases with plasma exchange indications.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical apheresis"
DOI: 10.1002/jca.22055
Abstract: Neonatal Fc receptor (FcRn) blockade may represent a mechanism similar to plasma exchange (PLEX) in reducing immunoglobulin levels and thus have a broad implication for apheresis practitioners. Although only efgartigimod received FDA approval for myasthenia… read more here.
Keywords: neonatal receptor; fcrn; receptor blockade; plasma exchange ... See more keywords
Human serum albumin presents isoform variants with altered neonatal Fc receptor interactions
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3733
Abstract: Human serum albumin (HSA) is the most abundant protein in plasma and presents the particularity, with IgG, to have an extraordinary long serum half‐life conferred by its interaction with the neonatal Fc receptor (FcRn). If… read more here.
Keywords: fcrn binding; hsa; human serum; neonatal receptor ... See more keywords
Regulation of the Human Fc-Neonatal Receptor alpha-Chain Gene FCGRT by MicroRNA-3181
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2294-0
Abstract: PurposeFCGRT encodes the alpha-chain component of the neonatal Fc receptor (FcRn). FcRn is critical for the trafficking of endogenous and exogenous IgG molecules and albumin in various tissues. Few regulators of FcRn expression have been… read more here.
Keywords: mir 3181; hsa mir; alpha chain; expression ... See more keywords
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis
Sign Up to like & getrecommendations! Published in 2024 at "Immunologic Research"
DOI: 10.1007/s12026-024-09565-7
Abstract: The inhibition of the neonatal Fc receptor (FcRn) is a promising therapeutic pathway in certain autoimmune disorders to reduce the amount of circulating pathogenic IgG autoantibodies by interfering with their recycling system. FcRn antibodies are… read more here.
Keywords: disease; antibody; receptor fcrn; model ... See more keywords
Neonatal Fc receptor-targeted lignin-encapsulated porous silicon nanoparticles for enhanced cellular interactions and insulin permeation across the intestinal epithelium
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2021.08.007
Abstract: Abstract Oral insulin delivery could change the life of millions of diabetic patients as an effective, safe, easy-to-use, and affordable alternative to insulin injections, known by an inherently thwarted patient compliance. Here, we designed a… read more here.
Keywords: lignin; insulin; neonatal receptor; porous silicon ... See more keywords
Neonatal Fc receptor inhibition enables adeno-associated virus gene therapy despite pre-existing humoral immunity.
Sign Up to like & getrecommendations! Published in 2023 at "Human gene therapy"
DOI: 10.1089/hum.2022.216
Abstract: Advances in adeno-associated virus-based gene therapy are transforming our ability to treat rare genetic disorders and address other unmet medical needs. However, the natural prevalence of anti-adeno-associated virus neutralizing antibodies in humans currently limits the… read more here.
Keywords: neonatal receptor; gene; associated virus; adeno associated ... See more keywords
Targeting the neonatal Fc receptor in pemphigus: safety first
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Dermatology"
DOI: 10.1111/bjd.20939
Abstract: histochemical characterization of a mucin-like glycoprotein expressed in early stage breast carcinoma. Tumor Biol 2002; 23:263–78. 4 Conley SJ, Bosco EE, Tice DA et al. HER2 drives Mucin-like 1 to control proliferation in breast cancer… read more here.
Keywords: receptor pemphigus; neonatal receptor; dermatology; pemphigus safety ... See more keywords
Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.
Sign Up to like & getrecommendations! Published in 2023 at "PloS one"
DOI: 10.1371/journal.pone.0284636
Abstract: Podocytes are key to preventing the filtration of serum proteins into the urine. Recent evidence also suggests that in immune mediated kidney diseases, podocytes are the targets of immune complexes (ICs). The mechanisms whereby podocytes… read more here.
Keywords: neonatal receptor; cultured podocytes; knockout neonatal; alters immune ... See more keywords
The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection?
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1013285
Abstract: The neonatal Fc receptor (FcRn), well-known for mediating the transfer of maternal immunoglobulin G (IgG) to neonates, plays a critical role in neonatal antimicrobial defenses. Furthermore, FcRn regulates IgG and albumin homeostasis via pH-dependent recycling… read more here.
Keywords: receptor fcrn; infection; neonatal receptor; fcrn ... See more keywords
The neonatal Fc receptor expression during macrophage differentiation is related to autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1054425
Abstract: The neonatal Fc receptor (FcRn) plays a central role in recycling and biodistributing immunoglobulin G. FcRn is also involved in many physiological immune functions as well as pathological immune responses in cancer or autoimmune diseases.… read more here.
Keywords: neonatal receptor; expression; anti inflammatory; fcrn ... See more keywords