Utility of Rapid Sequence Magnetic Resonance Imaging in Guiding Management of Patients With Neonatal Seizures.
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2019.08.001
Abstract: OBJECTIVE To determine whether the use of rapid sequence magnetic resonance imaging (rsMRI) is associated with improved efficiency of care when managing infants with suspected neonatal onset seizures. METHODS We conducted a preintervention and postintervention… read more here.
Keywords: rapid sequence; patients neonatal; neonatal seizures; sequence magnetic ... See more keywords
Recommendations for the design of therapeutic trials for neonatal seizures
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DOI: 10.1038/s41390-018-0242-2
Abstract: Although seizures have a higher incidence in neonates than any other age group and are associated with significant mortality and neurodevelopmental disability, treatment is largely guided by physician preference and tradition, due to a lack… read more here.
Keywords: group; trials neonatal; neonatal seizures; design therapeutic ... See more keywords
EEG in neonatal seizures: where to look and what to see
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2022.2169132
Abstract: ABSTRACT Introduction Neonatal seizures are frequent and carry a detrimental prognostic outlook. Diagnosis is based on EEG confirmation. Classification has recently changed. Areas covered We consulted original papers, book chapters, atlases, and reviews to provide… read more here.
Keywords: seizures look; look see; eeg neonatal; neonatal seizures ... See more keywords
Acrodermatitis enteropathica‐like skin eruption with neonatal seizures in a child with biotinidase deficiency
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DOI: 10.1111/ced.14053
Abstract: An 8-year-old boy presented with recurrent seizures starting from day 6 of birth and skin lesions around the eyes and lips since 1-year of age. Face was involved in the form of adherent scaling and… read more here.
Keywords: acrodermatitis enteropathica; enteropathica like; skin eruption; neonatal seizures ... See more keywords
Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain‐of‐function variant
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DOI: 10.1111/epi.13601
Abstract: Variants in KCNQ2 encoding for Kv7.2 neuronal K+ channel subunits lead to a spectrum of neonatal‐onset epilepsies, ranging from self‐limiting forms to severe epileptic encephalopathy. Most KCNQ2 pathogenic variants cause loss‐of‐function, whereas few increase channel… read more here.
Keywords: infantile spasms; r198q; neonatal seizures; function ... See more keywords
A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia"
DOI: 10.1111/epi.16912
Abstract: Bumetanide was suggested as an adjunct to phenobarbital for suppression of neonatal seizures. This suggestion was based on the idea that bumetanide, by reducing intraneuronal chloride accumulation through inhibition of the Na‐K‐2Cl cotransporter NKCC1, may… read more here.
Keywords: neonatal seizures; birth asphyxia; rat model;
The debate on the treatment of neonatal seizures: Introductory remarks
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17275
Abstract: Despite the development of new antiepileptic drugs, including those aimed at treating the pediatric population, little clinical research has been focused on neonatal seizures, a large proportion of which fail to respond to treatment. Phenobarbital… read more here.
Keywords: treatment neonatal; birth asphyxia; seizures introductory; treatment ... See more keywords
Finally, a controversy about neonatal seizure treatment
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17277
Abstract: Finally, we have some controversy to publish about neonatal seizure treatment. "Controversy in Epilepsy" has been an underused section of Epilepsia in recent years. Epilepsia offers this manuscript section believing that scientific controversy is an… read more here.
Keywords: etiology; brain; epilepsy; treatment ... See more keywords
Clarifications regarding bumetanide for neonatal seizures
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DOI: 10.1111/epi.17278
Abstract: A recent Phase II randomized, controlled trial of bumetanide as an adjunctive treatment for neonatal seizures showed a robust efficacy signal and no evidence of toxicity. Concerns regarding bumetanide as an adjunctive anticonvulsant are addressed… read more here.
Keywords: bumetanide neonatal; clarifications regarding; neonatal seizures; regarding bumetanide ... See more keywords
Bumetanide for neonatal seizures: No light in the pharmacokinetic/dynamic tunnel
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17279
Abstract: In his editorial, Kevin Staley criticizes our recent work demonstrating the lack of effect of bumetanide in a novel model of neonatal seizures. The main points in our response are that (1) our work is… read more here.
Keywords: brain; light pharmacokinetic; bumetanide neonatal; neonatal seizures ... See more keywords
Clinical manifestations of neonatal seizures
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DOI: 10.1111/ped.14654
Abstract: Neonatal seizures present a unique diagnostic challenge with clinical manifestations often subtle or absent to the bedside observer. Seizures can be overdiagnosed in newborns with unusual paroxysmal movements and underdiagnosed in newborns without clinical signs… read more here.
Keywords: diagnosis; manifestations neonatal; neonatal seizures; seizures clinical ... See more keywords