Extrapolation of Midazolam Disposition in Neonates Using Physiological‐Based Pharmacokinetic/Pharmacodynamic Modeling
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DOI: 10.1002/cpdd.1531
Abstract: There is a shortage of data in clinical studies of neonatal populations, which often utilize extrapolation strategies and model simulation techniques to support drug development and clinical applications. This study established an adult physiological‐based pharmacokinetic/pharmacodynamic… read more here.
Keywords: neonates using; based pharmacokinetic; physiological based; extrapolation ... See more keywords
Measurement of Airway Length in Neonates Using Fiberoptic Bronchoscopy.
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DOI: 10.1111/pan.70028
Abstract: Optimal positioning of the endotracheal tube is a crucial step in the airway management of neonates. Short airway length creates a narrow margin of safety and thus a higher chance of ETT malpositioning. Published literature… read more here.
Keywords: neonates using; fiberoptic bronchoscopy; measurement airway; length neonates ... See more keywords
Physiologically-based pharmacokinetic modelling and dosing evaluation of gentamicin in neonates using PhysPK
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.977372
Abstract: Each year, infections caused around the 25% of neonatal deaths. Early empirical treatments help to reduce this mortality, although optimized dosing regimens are still lacking. The aims were to develop and validate a gentamicin physiologically-based… read more here.
Keywords: neonates using; pbpk model; based pharmacokinetic; physiologically based ... See more keywords