Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.11.017
Abstract: OBJECTIVES There has been recent renewed interest in historical antibiotics because of the increased antibiotic-resistant bacterial strains. Latamoxef, a semi-synthetic oxacephem antibiotic developed in 1980s, has recently been brought back into use for treatment of… read more here.
Keywords: latamoxef neonates; latamoxef; neonates young; young infants ... See more keywords
Ceftolozane/Tazobactam in Neonates and Young Infants: The Challenges of Collecting Pharmacokinetics and Safety Data in This Vulnerable Patient Population.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of perinatology"
DOI: 10.1055/s-0039-3402719
Abstract: OBJECTIVE New treatments are needed for multidrug-resistant (MDR) gram-negative infections in neonates. Ceftolozane/tazobactam is a β-lactam/β-lactamase inhibitor combination that has broad-spectrum activity against most common gram-negative bacteria, including MDR strains. We evaluated pharmacokinetics (PK) and… read more here.
Keywords: ceftolozane tazobactam; safety; neonates young; young infants ... See more keywords
Pharmacokinetics and Safety of Ceftazidime-Avibactam in Neonates and Young Infants: A Phase 2a, Multicenter Prospective Trial
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DOI: 10.1093/jpids/piaf028
Abstract: Abstract Background This phase 2a study evaluated pharmacokinetics and safety of ceftazidime-avibactam (CAZ/AVI; combination dosed as fixed 4:1 ratio) in neonates and young infants with suspected/confirmed infections due to Gram-negative pathogens requiring intravenous antibiotics. Methods… read more here.
Keywords: caz avi; young infants; part; neonates young ... See more keywords
Asymptomatic Adults and Children Can Transmit Human Parechoviruses and Enteroviruses to Neonates and Young Infants
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DOI: 10.1093/ofid/ofx163.1170
Abstract: Abstract Background Human parechovirus (HPeV) type 3 and enteroviruses (EVs) are the common viruses causing severe diseases in neonates and young infants. Given no specific therapy is currently available and the morbidity and mortality of… read more here.
Keywords: stool samples; family members; hpevs evs; neonates young ... See more keywords
Update on nonpolio enterovirus and parechovirus infections in neonates and young infants
Sign Up to like & getrecommendations! Published in 2023 at "Current Opinion in Pediatrics"
DOI: 10.1097/mop.0000000000001236
Abstract: Purpose of review To review the epidemiology, clinical manifestations, and treatment strategies of nonpolio enterovirus and parechovirus (PeV) infections, and identify research gaps. Recent findings There is currently no approved antiviral agent for enterovirus or… read more here.
Keywords: enterovirus; young infants; neonates young; enterovirus parechovirus ... See more keywords
Population Pharmacokinetics and Dosing Optimization of Amoxicillin in Neonates and Young Infants
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DOI: 10.1128/aac.02336-18
Abstract: Amoxicillin is widely used to treat bacterial infections in neonates. However, considerable intercenter variability in dosage regimens of antibiotics exists in clinical practice. ABSTRACT Amoxicillin is widely used to treat bacterial infections in neonates. However,… read more here.
Keywords: population pharmacokinetics; neonates young; young infants; dosage ... See more keywords
O-13 Factors impacting unbound vancomycin concentrations in neonates and young infants
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2017-esdppp.13
Abstract: Background Vancomycin, a glycopeptide, is often ad-ministered to treat (suspected) serious gram-positive in-fections caused by Staphylococci, including methicillin-re-sistant Staphylococcus aureus (MRSA) and coagulase-neg-ative Staphylococci (CoNS). Vancomycin pharmacokinetic (PK) and pharmacodynamic (PD) data in neonates are… read more here.
Keywords: vancomycin; vancomycin concentration; neonates young; young infants ... See more keywords
Definitive treatment of seizures due to hemimegalencephaly in neonates and young infants by transarterial embolization: technical considerations for ‘endovascular embolic hemispherectomy’
Sign Up to like & getrecommendations! Published in 2022 at "Journal of NeuroInterventional Surgery"
DOI: 10.1136/jnis-2022-019049
Abstract: Background This case series describes the technical considerations and effectiveness of ‘endovascular embolic hemispherectomy’ for the treatment of medically intractable seizures in neonates and young infants with hemimegalencephaly (HME) and in whom surgical hemispherectomy is… read more here.
Keywords: hemispherectomy; young infants; neonates young; embolization ... See more keywords