The upregulation of Pim kinases is essential in coordinating the survival, proliferation, and migration of KIT D816V-mutated neoplastic mast cells.
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia research"
DOI: 10.1016/j.leukres.2019.106166
Abstract: About ˜80% of mast cell neoplasm patients harbor the c-Kit activating mutation D816 V, which is associated with c-Kit inhibitor resistance and poor prognosis. However, the molecular basis for these effects is not fully known. To… read more here.
Keywords: pim; d816; pim kinases; neoplastic mast ... See more keywords
M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells
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DOI: 10.1371/journal.pone.0175514
Abstract: Gain-of-function mutations in Kit receptor tyrosine kinase result in the development of a variety of cancers, such as mast cell tumours, gastrointestinal stromal tumours (GISTs), acute myeloid leukemia, and melanomas. The drug imatinib, a selective… read more here.
Keywords: akt; pathway neoplastic; mast cells; kit ... See more keywords
CDK4/CDK6 Inhibitors Synergize with Midostaurin, Avapritinib, and Nintedanib in Inducing Growth Inhibition in KIT D816V+ Neoplastic Mast Cells
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DOI: 10.3390/cancers14133070
Abstract: Simple Summary Advanced systemic mastocytosis (AdvSM) is a rare malignant disease with a poor prognosis due to the drug resistance of neoplastic mast cells. We found that drugs targeting the cell cycle regulators CDK4 and… read more here.
Keywords: growth; cdk6 inhibitors; mast cells; cdk4 cdk6 ... See more keywords
Luteinizing Hormone Receptor Expression in Neoplastic Mast Cells Is Increased in Spayed and Neutered Dogs.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Animal Hospital Association"
DOI: 10.5326/jaaha-ms-7150
Abstract: Luteinizing hormone receptors (LHRs) are expressed in canine lymphoma and hemangiosarcoma. We hypothesized that LHR would be expressed in canine mast cell tumors (MCTs) and that more neoplastic mast cells would express LHR in gonadectomized… read more here.
Keywords: gonadectomized dogs; mast; expression; mast cells ... See more keywords