Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression
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DOI: 10.1002/cam4.4447
Abstract: Barrett's esophagus is a widespread chronically progressing disease of heterogeneous nature. A life threatening complication of this condition is neoplastic transformation, which is often overlooked due to lack of standardized approaches in diagnosis, preventative measures… read more here.
Keywords: barrett; neoplastic progression; barrett esophagus; esophagus pathomorphological ... See more keywords
Genome‐wide analysis of colorectal cancer based on gene‐based somatic copy number alterations during neoplastic progression within the same tumor
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DOI: 10.1002/cam4.5117
Abstract: The objective of this study was to elucidate the association between neoplastic progression and somatic copy number alterations (SCNAs) occurring within the same colorectal cancer (CRC) tumor. read more here.
Keywords: number alterations; somatic copy; neoplastic progression; colorectal cancer ... See more keywords
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
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DOI: 10.1016/j.ccell.2017.10.011
Abstract: Despite expression of oncogenic KRAS, premalignant pancreatic intraepithelial neoplasia 1 (PanIN1) lesions rarely become fully malignant pancreatic ductal adenocarcinoma (PDAC). The molecular mechanisms through which established risk factors, such as chronic pancreatitis, acinar cell damage,… read more here.
Keywords: stress activated; pdac; mdm2; neoplastic progression ... See more keywords
Molecular Predictors of Gastric Neoplastic Progression.
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DOI: 10.1016/j.ccell.2017.12.006
Abstract: In this issue of Cancer Cell, Huang et al. describe comprehensive genetic and epigenetic profiling of gastric intestinal metaplasia lesions from a longitudinal cohort in which outcome data allowed for identification of potential markers of gastric… read more here.
Keywords: neoplastic progression; predictors gastric; molecular predictors; gastric neoplastic ... See more keywords
Detection of genetic alterations in cfDNA as a possible strategy to monitor the neoplastic progression of Barrett's esophagus
Sign Up to like & getrecommendations! Published in 2017 at "Translational Research"
DOI: 10.1016/j.trsl.2017.09.004
Abstract: &NA; Barrett's esophagus (BE) is associated with an increased risk of developing esophageal adenocarcinoma. Despite the low absolute risk of neoplastic progression of BE, probability increases with the diagnosis of dysplasia. For this reason, BE… read more here.
Keywords: neoplastic progression; genetic alterations; monitor; barrett esophagus ... See more keywords
Differentially deregulated microRNAs as novel biomarkers for neoplastic progression in ulcerative colitis.
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DOI: 10.14309/ctg.0000000000000489
Abstract: BACKGROUND Colorectal cancer (CRC) is a potentially life-threatening complication of long-standing ulcerative colitis (UC). MicroRNAs are epigenetic regulators that have been involved in the development of UC associated CRC. However, their role as potential mucosal… read more here.
Keywords: neoplastic progression; biomarkers neoplastic; normal mucosa; ulcerative colitis ... See more keywords
Sex Differences in Neoplastic Progression in Barrett’s Esophagus: A Multicenter Prospective Cohort Study
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DOI: 10.3390/cancers14133240
Abstract: Simple Summary Barrett’s esophagus (BE) is the only known precursor lesion of esophageal adenocarcinoma (EAC). Endoscopic surveillance plays an important role in the timely detection of neoplastic progression. However, the cost-effectiveness of current surveillance strategies… read more here.
Keywords: time; neoplastic progression; progression; risk ... See more keywords