Rapid testing of candidate oncogenes and tumour suppressor genes in signal transduction and neoplastic transformation.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in biological regulation"
DOI: 10.1016/j.jbior.2021.100841
Abstract: The COSMIC database (version 94) lists 576 genes in the Cancer Gene Census which have a defined function as drivers of malignancy (oncogenes) or as tumour suppressors (Tier 1). In addition, there are 147 genes… read more here.
Keywords: rapid testing; oncogenes tumour; neoplastic transformation; transformation ... See more keywords
Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence
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DOI: 10.1038/s41598-021-89220-5
Abstract: Much in vivo evidence indicates that cyclooxygenase-2 (COX-2) is deeply involved in tumorigenesis. Although it has been proposed that COX-2-derived pro-inflammatory prostanoids mediate the tumorigenic activity of COX-2, the tumorigenic mechanisms of COX-2 are not… read more here.
Keywords: oncogene induced; neoplastic transformation; cox; induced senescence ... See more keywords
Genomic Loss and Epigenetic Silencing of the FOSL1 Tumor Suppressor Gene in Radiation-induced Neoplastic Transformation of Human CGL1 Cells Alters the Tumorigenic Phenotype In Vitro and In Vivo.
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DOI: 10.1667/rade-22-00216.1
Abstract: The CGL1 human hybrid cell system has been utilized for many decades as an excellent cellular tool for investigating neoplastic transformation. Substantial work has been done previously implicating genetic factors related to chromosome 11 to… read more here.
Keywords: gene; tumor suppressor; neoplastic transformation; radiation ... See more keywords
Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation
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DOI: 10.7554/elife.68394
Abstract: Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness. Intriguingly, stem/progenitor cells maintaining repressed… read more here.
Keywords: stem progenitor; mitochondrial fission; neoplastic transformation; progenitor ... See more keywords