PD59-01 INSM1 IS A DRIVER OF NEUROENDOCRINE PROSTATE CANCER
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000969.01
Abstract: INTRODUCTION AND OBJECTIVE: Neuroendocrine prostate cancer (NEPC), arising mostly from adenocarcinoma via NE transdifferentiation following androgen deprivation therapy, is a lethal subtype of prostate cancer (PCa). Mechanisms contributing to NEPC development and its aggressiveness remain… read more here.
Keywords: nepc; insm1; prostate; neuroendocrine prostate ... See more keywords
ASCL1 regulates and cooperates with FOXA2 to drive terminal neuroendocrine phenotype in prostate cancer
Sign Up to like & getrecommendations! Published in 2024 at "JCI Insight"
DOI: 10.1172/jci.insight.185952
Abstract: Lineage plasticity mediates resistance to androgen receptor pathway inhibitors (ARPIs) and progression from adenocarcinoma to neuroendocrine prostate cancer (NEPC), a highly aggressive and poorly understood subtype. Neuronal transcription factor ASCL1 has emerged as a central… read more here.
Keywords: ascl1; nepc; prostate cancer; lineage ... See more keywords