Key features of the nephrogenic zone in the fetal human kidney—hardly known but relevant for the detection of first traces impairing nephrogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Cell and Tissue Research"
DOI: 10.1007/s00441-018-2937-4
Abstract: In healthy newborn babies, nephrogenesis proceeds unnoticed until birth. With start of the perinatal period, morphogenetic activity in the renal outer cortex consisting of an inner maturation zone and an outer nephrogenic zone is downregulated… read more here.
Keywords: features nephrogenic; zone; nephrogenic zone; key features ... See more keywords
Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26626-9
Abstract: Mammalian nephron endowment is determined by the coordinated cessation of nephrogenesis in independent niches. Here we report that translatome analysis in Tsc1+/− nephron progenitor cells from mice with elevated nephron numbers reveals how differential translation… read more here.
Keywords: wnt; increase; nephron; nephrogenesis ... See more keywords
Repair after nephron ablation reveals limitations of neonatal neonephrogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.88848
Abstract: The neonatal mouse kidney retains nephron progenitor cells in a nephrogenic zone for 3 days after birth. We evaluated whether de novo nephrogenesis can be induced postnatally beyond 3 days. Given the long-term implications of… read more here.
Keywords: nephron ablation; novo nephrogenesis; repair nephron; ablation reveals ... See more keywords
Effect of Calcitriol on the Renal Microvasculature Differentiation Disturbances Induced by AT1 Blockade During Nephrogenesis in Rats
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DOI: 10.3389/fmed.2020.00023
Abstract: Alterations in the renal vasculature during fetal programming can cause disturbances in renal structure and function that persist into adulthood. Calcitriol can affect cellular differentiation and proliferation, and promote endothelial cell maintenance, each of which… read more here.
Keywords: at1 blockade; microvasculature differentiation; renal microvasculature; calcitriol ... See more keywords
Renal Medullary Carcinomas Harbor a Distinct Methylation Phenotype and Display Aberrant Methylation of Genes Related to Early Nephrogenesis
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DOI: 10.3390/cancers14205044
Abstract: Simple Summary Renal medullary carcinomas (RMC) are aggressive tumors of the kidneys, characterized by a loss of SMARCB1. As the tumors, arising predominantly in young males with sickle cell trait, are very rare and no… read more here.
Keywords: methylation; renal medullary; nephrogenesis; medullary carcinomas ... See more keywords