RNA-Seq and protein mass spectrometry in microdissected kidney tubules reveal signaling processes initiating lithium-induced nephrogenic diabetes insipidus.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.02.015
Abstract: Lithium salts, used for treating bipolar disorder, frequently induce nephrogenic diabetes insipidus (NDI) thereby limiting therapeutic success. NDI is associated with loss of expression of the gene coding for the molecular water channel, aquaporin-2, in… read more here.
Keywords: nephrogenic diabetes; lithium induced; diabetes insipidus; rna seq ... See more keywords
Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
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DOI: 10.1038/ncomms14577
Abstract: NF-E2-related factor-2 (Nrf2) regulates cellular responses to oxidative and electrophilic stress. Loss of Keap1 increases Nrf2 protein levels, and Keap1-null mice die of oesophageal hyperkeratosis because of Nrf2 hyperactivation. Here we show that deletion of… read more here.
Keywords: null mice; hyperactivation; keap1 null; nephrogenic diabetes ... See more keywords
Dynamics and energetics of water transport through aquaporin mutants causing nephrogenic diabetes insipidus (NDI): A molecular dynamics study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1824813
Abstract: Abstract Human aquaporin-2 (AQP2) is the principal water channel in the human kidney. Any alteration of its physiological functioning may lead to the water imbalance and consequently diseases in humans, especially nephrogenic diabetes insipidus (NDI).… read more here.
Keywords: aquaporin; diabetes insipidus; water; insipidus ndi ... See more keywords
Congenital nephrogenic diabetes insipidus presenting as osmotic demyelination syndrome in infancy
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000028552
Abstract: Abstract Rationale: Almost 90% of congenital nephrogenic diabetes insipidus (NDI) cases are caused by mutations in the arginine vasopressin receptor 2 gene, which has X-linked recessive inheritance. Although NDI is commonly diagnosed in early infancy… read more here.
Keywords: osmotic demyelination; congenital nephrogenic; nephrogenic diabetes; diagnosis ... See more keywords
G234(P) Nephrogenic diabetes insipidus in a female infant
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-rcpch.228
Abstract: Aim Nephrogenic Diabetes Insipidus (NDI) is rare. 90% of cases are due to a defect in the AVPR2 gene which is widely believed to be inherited in an X-linked recessive pattern; from asymptomatic carrier mothers,… read more here.
Keywords: avpr2 gene; g234 nephrogenic; linked recessive; nephrogenic diabetes ... See more keywords
Bendamustine-induced nephrogenic diabetes insipidus – A case report
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/10781552211013878
Abstract: Introduction In patients with relapsed or refractory lymphoma, high-dose chemoimmunotherapy with subsequent autologous hematopoietic cell transplantation (HCT) is a standard of care. Bendamustine, an alkylating agent, is used in the BeEAM (bendamustine, etoposide, cytarabine, melphalan)… read more here.
Keywords: diabetes insipidus; case report; bendamustine; bendamustine induced ... See more keywords
Phenotype heterogeneity of congenital adrenal hyperplasia due to genetic mosaicism and concomitant nephrogenic diabetes insipidus in a sibling
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DOI: 10.1186/s12881-018-0629-2
Abstract: BackgroundCongenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder caused by mutations in the CYP21A2. Congenital nephrogenic diabetes insipidus (NDI) is a rare X-linked recessive or autosomal recessive disorder caused… read more here.
Keywords: mosaicism; adrenal hyperplasia; genetic mosaicism; nephrogenic diabetes ... See more keywords
Atorvastatin in the treatment of Lithium-induced nephrogenic diabetes insipidus: the protocol of a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2018 at "BMC Psychiatry"
DOI: 10.1186/s12888-018-1793-9
Abstract: BackgroundLithium is the gold-standard treatment for bipolar disorder, is highly effective in treating major depressive disorder, and has anti-suicidal properties. However, clinicians are increasingly avoiding lithium largely due to fears of renal toxicity. Nephrogenic Diabetes… read more here.
Keywords: trial; randomized controlled; lithium; nephrogenic diabetes ... See more keywords
Gradient washout and secondary nephrogenic diabetes insipidus after brain injury in an infant: a case report
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DOI: 10.1186/s13256-020-02536-0
Abstract: Disorders of water and sodium balance can occur after brain injury. Prolonged polyuria resulting from central diabetes insipidus and cerebral salt wasting complicated by gradient washout and a type of secondary nephrogenic diabetes insipidus, however,… read more here.
Keywords: case; gradient washout; nephrogenic diabetes; secondary nephrogenic ... See more keywords
Congenital nephrogenic diabetes insipidus due to the mutation in AVPR2 (c.541C>T) in a neonate: A case report
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v8.i24.6418
Abstract: BACKGROUND Congenital nephrogenic diabetes insipidus (CNDI) is a rare hereditary renal disorder that is caused by mutations in AVPR2 or aquaporin 2 (AQP2). Up to now, there are few reports about CNDI in neonates. Early… read more here.
Keywords: case; cndi; congenital nephrogenic; nephrogenic diabetes ... See more keywords
Congenital nephrogenic diabetes insipidus in the Corpus Hippocraticum: The first description
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DOI: 10.14310/horm.2002.1736
Abstract: In congenital nephrogenic diabetes insipidus (cNDI), polyuria and polydipsia are present from birth, as the kidney is unable to concentrate urine despite elevated concentrations of the antidiuretic hormone arginine-vasopressin.1 In ancient Greek medicine, physiology was,… read more here.
Keywords: corpus hippocraticum; hippocraticum first; insipidus corpus; congenital nephrogenic ... See more keywords