A nephron model for study of drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.11.010
Abstract: In this study, we developed a multilayer microfluidic device to simulate nephron, which was formed by "glomerulus", "Bowman's capsule", "proximal tubular lumen" and "peritubular capillary". In this microdevice, artificial renal blood flow was circulating and… read more here.
Keywords: assessment drug; induced nephrotoxicity; drug induced; drug ... See more keywords
AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.05.026
Abstract: The developmental mechanisms that orchestrate differentiation of specific nephron segments are incompletely understood, and the factors that maintain their terminal differentiation after nephrogenesis remain largely unknown. Here, the transcription factor AP-2β is shown to be… read more here.
Keywords: terminal differentiation; kctd1; renal fibrosis; differentiation ... See more keywords
Single-Nephron GFR in Patients With Obesity-Related Glomerulopathy
Sign Up to like & getrecommendations! Published in 2020 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2020.05.013
Abstract: Introduction Obesity-related glomerulopathy (ORG) is a slowly progressive kidney disease occurring in association with obesity. It is characterized histopathologically by glomerulomegaly, likely caused by single-nephron hyperfiltration that has not been demonstrated in humans because of… read more here.
Keywords: single nephron; related glomerulopathy; obesity related; nephron ... See more keywords
Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01922-5
Abstract: Animal fetuses and embryos may have applications in the generation of human organs. Progenitor cells may be an appropriate cell source for regenerative organs because of their safety and availability. However, regenerative organs derived from… read more here.
Keywords: progenitor cells; cell; generation; nephron progenitor ... See more keywords
Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26626-9
Abstract: Mammalian nephron endowment is determined by the coordinated cessation of nephrogenesis in independent niches. Here we report that translatome analysis in Tsc1+/− nephron progenitor cells from mice with elevated nephron numbers reveals how differential translation… read more here.
Keywords: wnt; increase; nephron; nephrogenesis ... See more keywords
PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04813-3
Abstract: The kidney is formed by reciprocal interactions between the nephron progenitor and the ureteric bud, the former of which gives rise to the epithelia of nephrons consisting of glomeruli and renal tubules. The transcription factor… read more here.
Keywords: human induced; nephron progenitors; pluripotent stem; induced pluripotent ... See more keywords
Regulation of Distal Nephron Transport by Intracellular Chloride and Potassium
Sign Up to like & getrecommendations! Published in 2022 at "Nephron"
DOI: 10.1159/000526051
Abstract: Background: Low potassium increases the phosphorylation and activity of the sodium chloride cotransporter (NCC) in the distal convoluted tubule of the nephron, which contributes to the hypertensive effect of the modern low potassium/high sodium diet.… read more here.
Keywords: nephron; potassium; intracellular chloride; distal ... See more keywords
A computational model of epithelial solute and water transport along a human nephron
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006108
Abstract: We have developed the first computational model of solute and water transport from Bowman space to the papillary tip of the nephron of a human kidney. The nephron is represented as a tubule lined by… read more here.
Keywords: computational model; solute; water transport; model ... See more keywords
Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus.
Sign Up to like & getrecommendations! Published in 2021 at "PloS one"
DOI: 10.1371/journal.pone.0246289
Abstract: BACKGROUND Here, we have demonstrated that gestational low-protein (LP) intake offspring present lower birth weight, reduced nephron numbers, renal salt excretion, arterial hypertension, and renal failure development compared to regular protein (NP) intake rats in… read more here.
Keywords: gestational low; low protein; expression; involved proliferation ... See more keywords
Segment-Dependent Gene Expression Profiling of the Cartilaginous Fish Nephron Using Laser Microdissection for Functional Characterization of Nephron at Segment Levels
Sign Up to like & getrecommendations! Published in 2023 at "Zoological Science"
DOI: 10.2108/zs220092
Abstract: For adaptation to a high salinity marine environment, cartilaginous fishes have evolved a ureosmotic strategy. They have a highly elaborate “four-loop nephron” in the kidney, which is considered to be important for reabsorption of urea… read more here.
Keywords: nephron; segment dependent; loop; gene expression ... See more keywords
Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.815249
Abstract: The vertebrate Six1 and Six2 arose by gene duplication from the Drosophila sine oculis and have since diverged in their developmental expression patterns. Both genes are expressed in nephron progenitors of human fetal kidneys, and… read more here.
Keywords: nephron; mouse; expression; six2 ... See more keywords