The intact nephron hypothesis as a model for renal drug handling
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2572-8
Abstract: PurposeThe intact nephron hypothesis (INH) states that impaired renal function results from a reduction in the number of complete (intact) nephrons. Under this model, renal drug clearance is assumed to be a linear function of… read more here.
Keywords: inh; renal drug; drug; intact nephron ... See more keywords
Chemical evidence for the tradeoff-in-the-nephron hypothesis to explain secondary hyperparathyroidism
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0272380
Abstract: Background Secondary hyperparathyroidism (SHPT) complicates advanced chronic kidney disease (CKD) and causes skeletal and other morbidity. In animal models of CKD, SHPT was prevented and reversed by reduction of dietary phosphate in proportion to GFR,… read more here.
Keywords: nephron hypothesis; secondary hyperparathyroidism; tradeoff nephron; pth ... See more keywords
An examination of multiple explanations for secondary hyperparathyroidism
.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical nephrology"
DOI: 10.5414/cn110043
Abstract: AIMS Seven theories address the evolution of secondary hyperparathyroidism (SHPT) as chronic kidney disease (CKD) progresses. The tradeoff-in-the-nephron hypothesis states that the plasma parathyroid hormone ([PTH]) concentration rises because an increased phosphate concentration in the… read more here.
Keywords: ccr; secondary hyperparathyroidism; nephron hypothesis; tradeoff nephron ... See more keywords