The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.05.008
Abstract: Chromatin-remodeling complexes play critical roles in establishing gene expression patterns in response to developmental signals. How these epigenetic regulators determine the fate of progenitor cells during development of specific organs is not well understood. We… read more here.
Keywords: brg1; proliferation; nephron progenitor; swi snf ... See more keywords
Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01922-5
Abstract: Animal fetuses and embryos may have applications in the generation of human organs. Progenitor cells may be an appropriate cell source for regenerative organs because of their safety and availability. However, regenerative organs derived from… read more here.
Keywords: progenitor cells; cell; generation; nephron progenitor ... See more keywords
Molecular determinants of WNT9b responsiveness in nephron progenitor cells
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DOI: 10.1371/journal.pone.0215139
Abstract: Primed nephron progenitor cells (NPCs) appear in metanephric mesenchyme by E11.5 and differentiate in response to the inductive WNT9b signal from the ureteric bud. However, the NPC WNT-receptor complex is unknown. We obtained M15 cells… read more here.
Keywords: progenitor cells; m15 cells; wnt9b responsiveness; nephron progenitor ... See more keywords
In vitro methods to ensure absence of residual undifferentiated human induced pluripotent stem cells intermingled in induced nephron progenitor cells
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0275600
Abstract: Cell therapies using human induced pluripotent stem cell (hiPSC)-derived nephron progenitor cells (NPCs) are expected to ameliorate acute kidney injury (AKI). However, using hiPSC-derived NPCs clinically is a challenge because hiPSCs themselves are tumorigenic. LIN28A,… read more here.
Keywords: pluripotent stem; hipsc derived; hipsc; nephron progenitor ... See more keywords
Regulation of Nephron Progenitor Cell Self-Renewal by Intermediary Metabolism.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016111246
Abstract: Nephron progenitor cells (NPCs) show an age-dependent capacity to balance self-renewal with differentiation. Older NPCs (postnatal day 0) exit the progenitor niche at a higher rate than younger (embryonic day 13.5) NPCs do. This behavior… read more here.
Keywords: glycolysis; self renewal; nephron progenitor; progenitor ... See more keywords
Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.40392
Abstract: A normal endowment of nephrons in the mammalian kidney requires a balance of nephron progenitor self-renewal and differentiation throughout development. Here, we provide evidence for a novel action of ureteric branch tip-derived Wnt11 in progenitor… read more here.
Keywords: determining nephron; wnt11; ultimately determining; nephron progenitor ... See more keywords