Motile nephron progenitors can exit and re-enter the niche over time
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.163
Abstract: Optogenetics allows precise, fast and reversible intervention in biological processes. Coupled with light-sheet microscopy, this approach allows unparalleled insight into the regulation of signaling pathways and cellular processes from a spatial and temporal perspective in… read more here.
Keywords: progenitors exit; wnt signaling; microscopy; motile nephron ... See more keywords
Some nephron progenitors fail to commit
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-019-0122-y
Abstract: A multiomics study by Adriana Hung, Todd Edwards and colleagues provides new insight into the genetic basis of blood pressure (BP) traits. “This work was motivated by important advances in the field that have enabled… read more here.
Keywords: nephron progenitors; association; expression; fail commit ... See more keywords
PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04813-3
Abstract: The kidney is formed by reciprocal interactions between the nephron progenitor and the ureteric bud, the former of which gives rise to the epithelia of nephrons consisting of glomeruli and renal tubules. The transcription factor… read more here.
Keywords: human induced; nephron progenitors; pluripotent stem; induced pluripotent ... See more keywords
Differentiation of CD117+ Amniotic Fluid Stem Cells towards Nephron Progenitors
Sign Up to like & getrecommendations! Published in 2022 at "Pakistan Journal of Medical Sciences"
DOI: 10.12669/pjms.38.6.4887
Abstract: Objective: The study aimed at isolation of CD117+ stem cells from amniotic fluid samples followed by their invitro differentiation towards nephron progenitors that can be potentially used for regenerative medicine studies and to further understand… read more here.
Keywords: amniotic fluid; towards nephron; fluid; nephron progenitors ... See more keywords
R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.53895
Abstract: During kidney development, WNT/β-catenin signalling has to be tightly controlled to ensure proliferation and differentiation of nephron progenitor cells. Here, we show in mice that the signalling molecules RSPO1 and RSPO3 act in a functionally… read more here.
Keywords: differentiation; nephron progenitors; nephron; spondin signalling ... See more keywords