Ombuin ameliorates diabetic nephropathy in rats by anti‐inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways
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DOI: 10.1002/ddr.21956
Abstract: Diabetic nephropathy (DN) is a common complication of diabetes and it is urgent to develop effective therapies for DN. In this study, high‐sucrose and high‐fat diet combined with streptozotocin was used to induce DN in… read more here.
Keywords: inflammation; ppar; ombuin ameliorates; ameliorates diabetic ... See more keywords
Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats
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DOI: 10.1002/ptr.6439
Abstract: Rhizome of Anemarrhena asphodeloides Bunge (AA, family Liliaceae) has been widely used in China for thousands of years to treat febrile diseases and diabetes. Steroidal saponins from AA show good antidiabetes effects and ameliorate diabetic… read more here.
Keywords: sarsasapogenin early; nephropathy rats; diabetic nephropathy; diabetic rats ... See more keywords
Impact of EGCG Supplementation on the Progression of Diabetic Nephropathy in Rats: An Insight into Fibrosis and Apoptosis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b03301
Abstract: Apoptosis is an active response of cells to altered microenvironments, which is characterized by cell shrinkage, chromatin condensation, and DNA fragmentation, in a variety of cell types such as renal epithelial cells, endothelial cells, mesangial… read more here.
Keywords: supplementation progression; apoptosis; nephropathy rats; impact egcg ... See more keywords
Evaluation of injury degree of adriamycin-induced nephropathy in rats based on serum metabolomics combined with proline marker.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00785
Abstract: Nephrotic syndrome (NS) is one of the leading causes of end-stage renal failure. Unfortunately, reliable surrogate markers for early diagnosing and monitoring the entire progression of NS are as yet absent. A method using UPLC-Q… read more here.
Keywords: adriamycin induced; nephropathy rats; proline; induced nephropathy ... See more keywords
Effect of the oral iron chelator deferiprone in diabetic nephropathy rats
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DOI: 10.1111/1753-0407.12420
Abstract: The aim of the present study was to investigate the effects of the iron chelator deferiprone in diabetic nephropathy (DN) rats and the mechanisms involved. read more here.
Keywords: iron chelator; chelator deferiprone; nephropathy rats; deferiprone diabetic ... See more keywords
Dexrazoxane Alleviated Doxorubicin-Induced Nephropathy in Rats
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DOI: 10.1159/000521220
Abstract: Introduction: Doxorubicin (DOX), an anthracycline antitumor agent, has been widely used against various solid tumors and hematological malignancies. However, the clinical application of DOX is restricted by its multiple organ toxicity including nephrotoxicity. This study… read more here.
Keywords: induced nephropathy; dox; dox induced; doxorubicin ... See more keywords
Rumex nervosus could alleviate streptozotocin-induced diabetic nephropathy in rats by activating Nrf2 signaling
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DOI: 10.1177/00368504221102751
Abstract: This study tested the protective effect of Rumex nervous (R. nervosus) methanol extract against streptozotocin (STZ)-mediated type 1 diabetes mellitus (T1DM)-induced nephropathy in rats and examined if this protection involves activating the nuclear factor erythroid… read more here.
Keywords: factor; activating nrf2; rumex nervosus; nephropathy rats ... See more keywords
Protective Effects of Total Glycoside From Rehmannia glutinosa Leaves on Diabetic Nephropathy Rats via Regulating the Metabolic Profiling and Modulating the TGF-β1 and Wnt/β-Catenin Signaling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01012
Abstract: Rehmannia glutinosa Libosch (RG), is officially listed in the Chinese Pharmacopoeia and is widely used in China. The leaves of RG (LR) is an important vegetative organ of the plant. At present, the total glycosides… read more here.
Keywords: nephropathy rats; diabetic nephropathy; total glycoside; tgf wnt ... See more keywords
Antidiabetic effects of Tetracarpidium conophorum seed on biomarkers of diabetes-induced nephropathy in rats
Sign Up to like & getrecommendations! Published in 2018 at "Asian Pacific Journal of Tropical Biomedicine"
DOI: 10.4103/2221-1691.248096
Abstract: Objective: To investigate antidiabetic effects of Tetracarpidium conophorum seed (TECOSE) against biomarkers of diabetes-induced nephropathy in rats. Methods: Powdered seed (500 g) of TECOSE was extracted with 5 L of 100% methanol for 72 h… read more here.
Keywords: seed; nephropathy rats; diabetes induced; body weight ... See more keywords