New insights into the vancomycin‐induced nephrotoxicity using in vitro metabolomics combined with physiologically based pharmacokinetic modeling
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DOI: 10.1002/jat.3951
Abstract: Vancomycin is a first‐line treatment for invasive infections caused by multidrug‐resistant gram‐positive bacteria. However, vancomycin‐induced nephrotoxicity is an increasing burden, particularly in patients with complex life‐threatening conditions. Vancomycin‐induced nephrotoxicity associated with clinically relevant exposure on… read more here.
Keywords: vancomycin; based pharmacokinetic; induced nephrotoxicity; physiologically based ... See more keywords
A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4093
Abstract: Aminoglycoside antibiotics are widely used for many life‐threatening infections. The use of aminoglycosides is often comprised by their deleterious side effects to the kidney and inner ear. A novel semisynthetic antibiotic, etimicin, has good antimicrobial… read more here.
Keywords: etimicin; hair cells; zebrafish embryos; ototoxicity ... See more keywords
In silico prediction of potential drug‐induced nephrotoxicity with machine learning methods
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DOI: 10.1002/jat.4331
Abstract: In recent years, drug‐induced nephrotoxicity has been one of the main reasons for the failure of drug development. Early prediction of the nephrotoxicity for drug candidates is critical to the success of clinical trials. Therefore,… read more here.
Keywords: drug induced; machine learning; prediction; drug ... See more keywords
Protective effects of recombinant human golimumab and pentoxifylline in nephrotoxicity induced by cisplatin
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22990
Abstract: In cisplatin‐induced nephrotoxicity, the significant role of activation of inflammatory pathways has been reported earlier. Studies indicate elevated expression and activity of tumor necrosis factor‐α (TNF‐α) in both, serum and kidneys of cisplatin‐treated animals. Golimumab,… read more here.
Keywords: inflammation; golimumab; oxidative stress; cisplatin ... See more keywords
Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway-mediated antioxidant response.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23344
Abstract: Polymyxin B (PMB) is a polypeptide antibiotic widely used in treating multidrug‐resistant Gram‐negative bacteria. However, nephrotoxicity is a serious adverse effect that limits its clinical use. Therefore, clarification of the molecular mechanism of PMB‐induced renal… read more here.
Keywords: nrf2 nqo1; nqo1 pathway; pmb; pmb induced ... See more keywords
Renal transporter OAT1 and PPAR‐α pathway co‐contribute to icaritin‐induced nephrotoxicity
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DOI: 10.1002/ptr.7633
Abstract: This study aimed to investigate the potential nephrotoxicity of icaritin and the underlying mechanism by in vitro–in vivo experiment technology combined with proteomics technology. First, icaritin showed a significant cytotoxic effect on HK‐2 cells, which… read more here.
Keywords: ppar; icaritin induced; renal transporter; icaritin ... See more keywords
Highlight report: mechanisms of nephrotoxicity and available in vitro systems
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02640-1
Abstract: Recently, Faria and colleagues from Utrecht University published a comprehensive review about the mechanisms of drug-induced kidney injury (Faria et al. 2019). Approximately 25% of serious adverse drug effects are due to druginduced nephrotoxicity (Malyszko… read more here.
Keywords: mechanisms nephrotoxicity; drug induced; drug; nephrotoxicity ... See more keywords
Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01673-8
Abstract: This study investigates the molecular mechanisms of the nephroprotective effect of piceatannol (PIC) against cisplatin-induced nephrotoxicity in rats. PIC (10 mg/kg i.p.) was given for 7 days, starting 2 days before cisplatin single injection (7 mg/kg i.p.). Serum creatinine, blood urea… read more here.
Keywords: hindering inflammatory; cisplatin induced; activation; pic ... See more keywords
Evaluation of the protective effect of edaravone on doxorubicin nephrotoxicity by [99mTc]DMSA renal scintigraphy and biochemical methods
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DOI: 10.1007/s00210-020-01832-2
Abstract: To evaluate the nephroprotective effect of edaravone on doxorubicin-induced nephrotoxicity. In this experimental study, twenty-eight Wistar male rats were used. The rats were separated into 4 groups (n = 7); group І (control), rats were treated with… read more here.
Keywords: effect; edaravone doxorubicin; nephrotoxicity; 99mtc dmsa ... See more keywords
Risk factors and clinical characteristics of tacrolimus-induced acute nephrotoxicity in children with nephrotic syndrome: a retrospective case-control study
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DOI: 10.1007/s00228-019-02781-3
Abstract: Purpose Acute nephrotoxicity is a common adverse reaction of tacrolimus therapy; however, its risk factors in pediatric nephrotic syndrome (NS) remain to be evaluated. The objective of this study was to investigate the risk factors… read more here.
Keywords: tacrolimus induced; nephrotoxicity; acute nephrotoxicity; risk factors ... See more keywords
Griffonia simplicifolia (DC.) Baill. attenuates gentamicin and cisplatin-induced nephrotoxicty in rats
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DOI: 10.1007/s00580-019-02934-x
Abstract: Nephrotoxicity is one of the most common kidney conditions. However, most conventional drugs are not adequate for treatment. This study was designed to evaluate the nephroprotective activity of 50% hydroethanolic leaf extract of Griffonia simplicifolia… read more here.
Keywords: cisplatin; gentamicin cisplatin; griffonia simplicifolia; nephrotoxicity ... See more keywords