Role of Neprilysin Inhibitors in Heart Failure
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DOI: 10.1097/mjt.0000000000000354
Abstract: Heart failure (HF) is a complex multifactorial medical condition that should be addressed according to its complexity and diversity. Currently, there is a medical arsenal available for the management of HF, but despite the advance… read more here.
Keywords: neprilysin inhibitors; role neprilysin; neprilysin; heart failure ... See more keywords
A novel mouse model of systemic hypertension by neprilysin overexpression in myeloid cells
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5729452
Abstract: There have been many hypertension mouse models created by transgenesis. The transgenesis technologies to create hypertensive mouse models mostly target the renin-angiotensin system (RAS). Here, we show that enhanced expression of neprilysin driven by the… read more here.
Keywords: hypertension; nep mice; neprilysin; systemic hypertension ... See more keywords
Neprilysin 4: an essential peptidase with multifaceted physiological relevance
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DOI: 10.1515/hsz-2022-0286
Abstract: Abstract Neprilysins are highly conserved ectoenzymes that hydrolyze and thus inactivate signaling peptides in the extracellular space. Herein, we focus on Neprilysin 4 from Drosophila melanogaster and evaluate the existing knowledge on the physiological relevance… read more here.
Keywords: neprilysin essential; peptidase; neprilysin; essential peptidase ... See more keywords
B-Type Natriuretic Peptide (BNP) Revisited—Is BNP Still a Biomarker for Heart Failure in the Angiotensin Receptor/Neprilysin Inhibitor Era?
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DOI: 10.3390/biology11071034
Abstract: Simple Summary Active BNP-32, less active proBNP-108, and inactive N-terminal proBNP-76 all circulate in the blood. The circulating protease neprilysin has lower substrate specificity for BNP than ANP, while proBNP and N-terminal proBNP are not… read more here.
Keywords: mature bnp; probnp; neprilysin; bnp ... See more keywords