Neuroprotective Effects of Galantamine on Nerve Agent-Induced Neuroglial and Biochemical Changes
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9815-9
Abstract: Neuroprotection from nerve agent such as soman-induced neural damage is a major challenge for existing drugs. Nerve agent exposure can cause many neural effects in survivors arising mainly due to acetylcholinesterase (AChE) inhibition or death… read more here.
Keywords: agent; exposure; soman; nerve agent ... See more keywords
Determination of nerve agent metabolites in human urine by femtosecond laser ionization mass spectrometry using 2-(bromomethyl)naphthalene as a derivatizing reagent.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.04.012
Abstract: Nerve agent metabolites (NAMs) derived from alkyl methyl phosphonic acids, such as ethyl methylphosphonic acid (EMPA), isopropyl methylphosphonic acid (IMPA), and pinacolyl methylphosphonic acid (PMPA), were extracted from human urine using diethyl ether as an… read more here.
Keywords: agent metabolites; mass spectrometry; ionization; human urine ... See more keywords
Graphene oxide/MnO2 nanocomposite as destructive adsorbent of nerve-agent simulants in aqueous media
Sign Up to like & getrecommendations! Published in 2017 at "Applied Surface Science"
DOI: 10.1016/j.apsusc.2017.03.228
Abstract: Abstract Graphene oxide/MnO 2 nanocomposite was prepared by thermal hydrolysis of potassium permanganate (KMnO 4 ) and 2-chloroacetamide aqueous solutions with graphene oxide (GO) suspension. The synthesized samples were characterized by specific surface area (BET)… read more here.
Keywords: graphene oxide; aqueous media; agent simulants; nerve agent ... See more keywords
Organophosphorus nerve agent poisoning: managing the poisoned patient.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2019.04.061
Abstract: Organophosphorus (OP) nerve agent poisoning made the headlines in 2018 with the nerve agent 'Novichok' poisonings in Salisbury, England. This event highlighted a gap in the knowledge of most clinicians in the UK. In response,… read more here.
Keywords: agent; poisoned patient; agent poisoning; organophosphorus nerve ... See more keywords
Chemical, biological, radiological, and nuclear mass casualty medicine: a review of lessons from the Salisbury and Amesbury Novichok nerve agent incidents.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2021.10.008
Abstract: On March 4, 2018, two casualties collapsed on a park bench in Salisbury, Wiltshire, UK. They were later discovered to have been the victims of an attempted murder using the Soviet-era Novichok class of nerve… read more here.
Keywords: medicine; review; nerve agent; salisbury amesbury ... See more keywords
Host-Guest interactions between nerve agent sarin and β-Cyclodextrin: A theoretical investigation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of The Taiwan Institute of Chemical Engineers"
DOI: 10.1016/j.jtice.2020.11.022
Abstract: Abstract β-cyclodextrins (β-CDs) are able to trap and hydrolyze certain nerve agents such as sarin. Herein, we studied the host-guest interactions of sarin with β-CD by performing quantum mechanical (QM) calculations and molecular dynamics (MD)… read more here.
Keywords: guest interactions; interactions nerve; sarin; host guest ... See more keywords
Leakage rate of the nerve agent tabun from sea-dumped munition.
Sign Up to like & getrecommendations! Published in 2020 at "Marine environmental research"
DOI: 10.1016/j.marenvres.2020.105052
Abstract: Tornes, John Aasulf; Vik, Thomas; Kjellstrom, Tomas Tungen. Leakage rate of the nerve agent tabun from sea-dumped munition. Marine Environmental Research 2020 ;Volum 161. read more here.
Keywords: tabun sea; rate nerve; leakage rate; agent tabun ... See more keywords
A delayed treatment model for the evaluation of scopolamine for VX nerve agent intoxication.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115650
Abstract: Most research on medical countermeasures for nerve agent exposure assumes a military scenario, in which (autoinjector) treatment is envisaged to be immediately available. In a civilian setting however, treatment is delayed until arrival of first-aid… read more here.
Keywords: scopolamine; treatment; exposure; delayed treatment ... See more keywords
Epigenetic and autophagic changes after nerve agent exposure in the rat piriform cortex and hippocampus.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.05.007
Abstract: The detrimental effects of organophosphate (OP) nerve agents have been reported but the mechanisms mediating these multiple effects are not well understood. Recent use of nerve agents in Syria and the UK illustrate their continuous… read more here.
Keywords: piriform cortex; exposure; nerve agent; cortex hippocampus ... See more keywords
Assessment of false transmitters as treatments for nerve agent poisoning.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.12.010
Abstract: Nerve agents inhibit acetylcholinesterase (AChE), leading to a build-up of acetylcholine (ACh) and overstimulation at cholinergic synapses. Current post-exposure nerve agent treatment includes atropine to treat overstimulation at muscarinic synapses, a benzodiazepine anti-convulsant, and an… read more here.
Keywords: overstimulation; treatments nerve; assessment false; false transmitters ... See more keywords
Contingency Medical Countermeasures for Mass Nerve-Agent Exposure: Use of Pharmaceutical Alternatives to Community Stockpiled Antidotes
Sign Up to like & getrecommendations! Published in 2018 at "Disaster Medicine and Public Health Preparedness"
DOI: 10.1017/dmp.2018.99
Abstract: ABSTRACT Having sufficient medical countermeasures (MCMs) available for the treatment of acetylcholinesterase-inhibiting nerve agent poisoned patients following a mass chemical exposure is a challenge for communities. After stockpiles containing auto-injectors are exhausted, communities need to… read more here.
Keywords: medical countermeasures; pharmaceutical alternatives; exposure; nerve agent ... See more keywords